SDHB NM_003000.3(SDHB):c.380T>G (p.Ile127Ser)

CI-VAR-00027124Explore in graph →p.Ile127SerNM_003000.3:c.380T>GClinVar 183814 rs786201095

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
183814	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Hereditary cancer-predisposing syndrome; Carney triad; Pheochromocytoma; Gastrointestinal stromal tumor; Pheochromocytoma/paraganglioma syndrome 4; Hereditary pheochromocytoma and paraganglioma; Mitochondrial complex 2 deficiency, nuclear type 4; Carney-Stratakis syndrome; Inherited phaeochromocytoma and paraganglioma excluding NF1; SDHB-related disorder	germline	19	Jan 11, 2026	clinvar