Variant · Snv
CHRNA5 NM_000745.4(CHRNA5):c.1192G>A (p.Asp398Asn)
CI-VAR-00006460Explore in graph →p.Asp398AsnNM_000745.4:c.1192G>AClinVar 17497 rs16969968
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-06
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260908-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 17497 | drug response | reviewed by expert panel | 3 | LUNG CANCER SUSCEPTIBILITY 2; SMOKING AS A QUANTITATIVE TRAIT LOCUS 3; nicotine response - Toxicity; Susceptibility to severe coronavirus disease (COVID-19) due to high levels of fibrinogen and C-reactive protein; Chronic obstructive pulmonary disease | germline | 4 | Mar 24, 2021 | clinvar |