Variant · Snv
TERT NM_198253.3(TERT):c.457C>T (p.Leu153=)
CI-VAR-00251152Explore in graph →p.Leu153=NM_198253.3:c.457C>TClinVar 1741626 rs2126689712
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-06
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260908-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 1741626 | Likely benign | criteria provided, multiple submitters, no conflicts | 2 | Idiopathic Pulmonary Fibrosis; Dyskeratosis congenita, autosomal dominant 2; Dyskeratosis congenita | germline | 2 | Mar 06, 2024 | clinvar |