Variant · Snv
COL1A2 NM_000089.4(COL1A2):c.2123G>A (p.Arg708Gln)
CI-VAR-00006457Explore in graph →p.Arg708GlnNM_000089.4:c.2123G>AClinVar 17250 rs72658163
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-24
- Retrieved
- Sep 29, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260929-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 17250 | Conflicting classifications of pathogenicity | criteria provided, conflicting classifications | 1 | Marfan syndrome, atypical; Connective tissue disorder; Ehlers-Danlos syndrome, arthrochalasia type, 2; Osteogenesis imperfecta; Postmenopausal osteoporosis; Ehlers-Danlos syndrome, classic type, 1; Osteogenesis imperfecta type I; Cardiovascular phenotype; Sarcoma; Cervical cancer; Malignant tumor of urinary bladder; Familial cancer of breast | germline | 14 | Jan 27, 2026 | clinvar |