Variant · Indel

BRCA1 NC_000017.11:g.43041660_43046086delinsCTGTG

CI-VAR-00242468Explore in graph →ClinVar 1713204

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
1713204	Pathogenic	no assertion criteria provided	0	Breast-ovarian cancer, familial, susceptibility to, 1	germline	1	Aug 26, 2022	clinvar

Nomenclature

Record

Gene: BRCA1
Type: Indel
HGVS g.: NC_000017.11:g.43041660_43046086delinsCTGTG
Assembly: GRCh38
Position: chr17:43041660-43046086
Ref / Alt: TGGCCCCACCTGTCTGGGATTCAGTGGGTCTGGGAATTTGCATATCTAACAAATTCCTAGGTGATGGTGTTGCCCCCTCACACTCCTATCAGGGGATCATGCTTTGAGAGCCTCTGCACTGAACTGTAAATGTTAAGCTGTCATATCATTTTGAGTCCTTGAAACCATGTCTCCACAGTTCATATTCCCCAGCCACCAGAGTCGGGAGGATCTCTCTCCAGATCTTGATTCCTACCAGTCCCTTAAACAATTGCTTACATTTTCCTGATCCTCCAGACATTCAGGATCAGCCCCTCTACACCTCCCCAATCCCTGCTCTCCATAGGAGCTGTTTCTAGTTTTCCTTAATTTTCTATTTGGCCAGATTCGTTGCTTTAATTTTCTCCTTGTTACAGGCAGAGTTACAGGCTGTTCAAGAAAACCAGGCATCACTGTAGTGGAAGGGGTTGCCGGCTCAGCCATTTTCCAGTAGTCTTTGATAAGTGAGCCCCCACATTCCCTGGGCAGCAGGCCCCATTCTCTAGGGCTTCTTTGCATAAATCTGCAGCTCCCCCTCATCCTGCCATTCTGTGTGTGCCATCTGCCTCTGGGGCTGACCTTATCTGCTCCTCGCAGCCTTCAGAGGACACCTTCTGGGCAGTTTGGCTCCTTCTGCTCCAACCACCCCAACATTGATTCCTTTCTTTTTCTCCTGCATATTTTTGAGGTGATACTTTGTTGATGATTCTGGTTGCATTTTTTAAGAGGGACATAATCTGCCAGAGCTCTTCTCTAGGCCCCCTCCCTGTGCCTGCATGATAATCCTTTCTCCTCCTTCCTTTCCAGCTTCTTTGTAGAAGTTTGTTTTGTAAAATGAGATAAAGGCAGTACAGGAACTAGTTCCCAATTGCTGCTGTGCCCAGAGAGGGCTAGAGATTGCGGGGTGGAAAAGTGGGAGGACATCTTAAAGTCAGAGGTCAAAGCAACGTGTATTAACTCCATCATCAGGTAGCACTCTTAACCTGGGCCAGGCACCATGAGGCCAGGGCCTGAACTTGACTTCTGGGAAAGGTTATGCAGAGCTTGAAACAGATGGGGTATATGTTTGTTGGGAGACCTTAGAGACAATTACAGAAAACTTTAATGTATTTTAGTCATCTTTGCTTTTACTCACTATTCCTGAAAAGGCAGGCTGTACTAGATGGATACTGCTTTTCCTATTAACCCATTAGTGATGGGGTCAGAAGGCTGAGGCCTGGCTTACCCTCAAGGCCCAGTAGCACTTCTGCTTGCTTCCCGCCTGCCTTTACTACTAACACCGAGACTCATCAACTCACTGGCAGGTAGACAGGGAGCTGGCATGGGCCCTTGGGAAGTCAAGCTGTAGGTGAGGATGAACTGGAAGGCTTTGACAACTAAGATACACAGTCATAAGCTGGGAAGCCAGAGAGAAGTGGAAACAGCAGCCATGATCCACTCCTGTAAGACCCTTTGCCTGACATGGGGCTGCTTTTACTGTCTCCTACTGTGGCCCAAAAGGGAAGTGAGTGTGAGTTCCCCTCAAAATCTAGTTCTCTCTCCAAATTCCCTTAAGGCTTGAACCTTCTGTCCCGGGGTCAGTGACAGAGGCAGATGGAAAGCTGATGATGGGAACAGAAAGGTGGCTTTGGGTCTCCATGTAGTCATTTTTAGCTGTGCAAATCTGAGTAAAATCTTACAAACAAGGAACTTGAGATTCAACTCCCATTTTTCCAATGAGGTAACAAATACCCACTTCATAGGGCTATGATGAAGACTGATATAAAATGTAATATTGGCAGTTAGCTCCATTTTCTCTATCTTCCTTCACTGTTTCCAGCAAATACAGCAGGACTGAACTATGTGATGACTTCATTCTCTTTGCTCAAAAAGGATTCCAATCTCTGAGCAGTGTGAGGACCAGGAAATAATGGTAGAGAGTGTCATCTGTGGATTAAGCATGTTAAATACAAGTGGTAGGCAGAATTCTAAAGATGTCCTCCCTTGATTGCTGTCTTCTGGTTATTCATTCCAACAGTAATCTAGGTACTGCTGCGAAGGGACTTTGCAGCTATAATTAAGGCTATGGGCCTTAAGATATGAAGATCACTTTGGATTACCAAGTGGGTGCAATCTAATCACTTGAGCCCTTAGAAACAGAGAAATGTCTCTGGCAGGAGTTAGAAAGATACAGTAGTCAGCAAGATTCAGTGTGAGAAAAACTTGACCACCCATTGCTGGTTTTGAAGATGGAGGCAGACAGGCCAGGAGCCTAGGAATGTGGGGAGCCTCAAGAAGCTGAGAATGATGCCCAGCCAACAGCCAGTGGGAAACAGGGATCTTAGTCCTAGAACTGCAAGGACCCAGAGCCTCTAGAAGGGAACACGCCCTGCGAACACCTTTATTTTGGCCTCATGAAACCTGAAACAAAGAAACAGTTGAGCCACCTCAGACTTCTGACCTTGCAACAATTTGTTTTGGCAGCAACAGGAAATACAAAAGGTATTTAAGCTGCCTCAATAAATCCTAGGAGGTAGATACTATCATTACCCCCATTTTACAGAGTGGGAGACTGAAGCACAGTGAAAAGGCTCTGAGAAAGTCGGCTGGCCTAAGTCTCAAGAACAGTCATTCATGGTGGAAGTGTTTGCTACCAAGTTTATTTGCAGTGTTAACAGCACAACATTTACAAAACGTATTTTGTACAATCAAGTCTTCACTGCCCTTGCACACTGGGGGGGCTAGGGAAGACCTAGTCCTTCCAACAGCTATAAACAGTCCTGGATAATGGGTTTATGAAAAACACTTTTTCTTCCTTCAGCAAGCAAAATTATTTATGAAGCTGTATGGTTTCAGCAACAGGGAGCAAAGGAAAAAAATCACCTCAAAGAAAGCAACAGCTTCCTTCCTGGTGGGATCTGTCATTTTATAGATATGAAATATTCATGCCAGAGGTCTTATATTTTAAGAGGAATGGATTATATACCAGAGCTACAACAATAAACATTTTACTTATTACTAATGAGGAATTAGAAGACTGTCTTTGGAAACCGGTTCTTGAAAATCTTCTGCTGTTTTAGAACACATTCTTTAGAAATCTAGCAAATATATCTCAGACTTTTAGAAATCTCTTCTAGTTTCATTTTCCTTTTTTTTTTTTTTTTTTTGAGCCACAGTCTCACTGTCACCCAGGCTGGAGTGCCGTGGTATGATCTTGGCTCACTGCAACCTCCACCTCCCGGGCTGAAGTGATTCTCCTGCCTTAGCCACCTGAGTAGCTGGGATTACAGGTGTCCACCACCATGACCGGCTAATTTCTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTTTCGAACTCCTGACCTCCAGTGATCTGCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCCAGGTTTCAAGTTTCCTTTTCATTTCTAATACCTGCCTCAGAATTTCCTCCCCAATGTTCCACTCCAACATTTGAGAACTGCCCAAGGACTATTCTGACTTTAAGTCACATAATCGATCCCAAGCACTCTCCTTCCATTGAAGGGTCTGACTCTCTGCCTTTGTGAACACAGGGTTTTAGAGAAGTAAACTTAGGGAAACCAGCTATTCTCTTGAGGCCAAGCCACTCTGTGCTTCCAGCCCTAAGCCAACAACAGCCTGAATAGAAAGAATAGGGCTGATAAATAATGAATCAGCATCTTGCTCAATTGGTGGCGTTTAAATGGTTTTAAAATCTTCTCAGGTGAAAAATTACCATAATTTTGTGCTCATGGCAGATTTCCAAGGGAGACTTCAAGCAGAAAATCTTTAAGGGACCCTTGCATAGCCAGAAGTCCTTTTCAGGCTGATGTACATAAAATATTTAGTAGCCAGGACAGTAGAAGGACTGAAGAGTGAGAGGAGCTCCCAGGGCCTGGAAAGGCCACTTTGTAAGCTCATTCTTGGGGTCCTGTGGCTCTGTACCTGTGGCTGGCTGCAGTCAGTAGTGGCTGTGGGGGATCTGGGGTATCAGGTAGGTGTCCAGCTCCTGGCACTGGTAGAGTGCTACACTGTCCAACACCCACTCTCGGGTCACCACAGGTGCCTCACACATCTGCCCAATTGCTGGAGACAGAGAACACAAGCAGAGATTAGTGTCAATTCATTCTCCTGGACTAGGCTCTAATCAATCGACTCCAGGGTCCTGGTTGTATGAGTTCTTAGGATTAATGAGGTAGAAGCTAATTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCGCCGAGGCTAGAGTGTGATGGCGCAATCTCGGCTCATTCAACCTCCGCCTCCTGGGTTCAAGCAATTCTCCTGTCTCTGCCTCCTGAGTAGCTGGAATTACAGGCACATGCCATCACACCCAGCT → CTGTG