POR NM_001395413.1(POR):c.850G>C (p.Ala284Pro)

CI-VAR-00006437Explore in graph →p.Ala284ProNM_001395413.1:c.850G>CClinVar 16902 rs121912974

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
16902	Pathogenic	criteria provided, multiple submitters, no conflicts	2	Antley-Bixler syndrome with genital anomalies and disordered steroidogenesis; Congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency; POR-related disorder; Differences in sex development; Inborn genetic diseases; Sarcoma; Cervical cancer	germline	16	Apr 21, 2026	clinvar