TSEN54 NM_207346.3(TSEN54):c.409A>C (p.Ile137Leu)

CI-VAR-00025138Explore in graph →p.Ile137LeuNM_207346.3:c.409A>CClinVar 160134 rs11559205

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
160134	Benign	criteria provided, multiple submitters, no conflicts	2	Pontoneocerebellar hypoplasia; Pontocerebellar hypoplasia type 5; Pontocerebellar hypoplasia type 2A; Pontocerebellar hypoplasia type 4; Colorectal cancer; Uterine carcinosarcoma; Cholangiocarcinoma; Adrenocortical carcinoma, hereditary; Uveal melanoma; Malignant lymphoma, large B-cell, diffuse; Lymphoma; Thymoma	germline	13	Feb 04, 2026	clinvar