GNAS NM_000516.7(GNAS):c.602G>A (p.Arg201His)

CI-VAR-00006341Explore in graph →p.Arg201HisNM_000516.7:c.602G>AClinVar 15934 rs121913495

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
15934	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	McCune-Albright syndrome; Sex cord-stromal tumor; Neoplasm; Pituitary adenoma 3, multiple types; Pseudohypoparathyroidism type I A; Inborn genetic diseases; ACTH-independent macronodular adrenal hyperplasia 1; Embryonal rhabdomyosarcoma	germline/somatic	13	Jan 26, 2026	clinvar