Variant · Snv
PIK3CA NM_006218.4(PIK3CA):c.353G>A (p.Gly118Asp)
CI-VAR-00024954Explore in graph →p.Gly118AspNM_006218.4:c.353G>AClinVar 156446 rs587777790
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-24
- Retrieved
- Sep 29, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260929-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 156446 | Pathogenic | criteria provided, multiple submitters, no conflicts | 2 | Cowden syndrome 5; Keratoacanthoma; Cowden syndrome; Angioosteohypertrophic syndrome; PIK3CA related overgrowth syndrome; Diffuse glioma, H3 G34 mutant; Dysembryoplastic neuroepithelial tumor; Embryonal rhabdomyosarcoma; Diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype; Neoplasm; PIK3CA-related disorder | germline/somatic | 11 | Nov 13, 2024 | clinvar |