MC1R NM_002386.4(MC1R):c.451C>T (p.Arg151Cys)

CI-VAR-00006311Explore in graph →p.Arg151CysNM_002386.4:c.451C>TClinVar 14312 rs1805007

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
14312	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications	1	Skin/hair/eye pigmentation 2, red hair/fair skin; Increased analgesia from kappa-opioid receptor agonist, female-specific; ALBINISM, OCULOCUTANEOUS, TYPE II, MODIFIER OF; Melanoma, cutaneous malignant, susceptibility to, 5; SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 2	germline	12	Feb 03, 2026	clinvar