MC1R NM_002386.4(MC1R):c.178G>T (p.Val60Leu)

CI-VAR-00006310Explore in graph →p.Val60LeuNM_002386.4:c.178G>TClinVar 14311 rs1805005

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
14311	Benign/Likely benign	criteria provided, multiple submitters, no conflicts	2	Skin/hair/eye pigmentation 2, blond hair/fair skin; Melanoma, cutaneous malignant, susceptibility to, 5; Malignant tumor of breast; Increased analgesia from kappa-opioid receptor agonist, female-specific; Tyrosinase-positive oculocutaneous albinism; SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 2	germline	10	Feb 04, 2026	clinvar