CHEK2 NM_007194.4(CHEK2):c.911T>C (p.Met304Thr)

CI-VAR-00023635Explore in graph →p.Met304ThrNM_007194.4:c.911T>CClinVar 141817 rs587782033

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
141817	Uncertain significance	criteria provided, multiple submitters, no conflicts	2	Hereditary cancer-predisposing syndrome; Familial cancer of breast; CHEK2-related disorder; Hereditary breast ovarian cancer syndrome	germline	10	Aug 11, 2026	clinvar