TP53 NM_000546.6(TP53):c.799C>T (p.Arg267Trp)

CI-VAR-00023582Explore in graph →p.Arg267TrpNM_000546.6:c.799C>TClinVar 141764 rs55832599

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
141764	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Hereditary cancer-predisposing syndrome; Li-Fraumeni syndrome; Lip and oral cavity carcinoma; Familial cancer of breast; Li-Fraumeni syndrome 1; Breast and/or ovarian cancer; Adrenocortical carcinoma, hereditary; TP53-related disorder; Medulloblastoma WNT activated; Neoplasm	germline/somatic	25	Jul 20, 2026	clinvar