MLH3 NM_001040108.2(MLH3):c.4357C>T (p.Pro1453Ser)

CI-VAR-00221573Explore in graph →p.Pro1453SerNM_001040108.2:c.4357C>TClinVar 1389392 rs1889930562

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
1389392	Uncertain significance	criteria provided, multiple submitters, no conflicts	2	Colorectal cancer, hereditary nonpolyposis, type 7	germline	2	Nov 18, 2025	clinvar