MCPH1 NM_024596.5(MCPH1):c.1738A>G (p.Ser580Gly)

CI-VAR-00022438Explore in graph →p.Ser580GlyNM_024596.5:c.1738A>GClinVar 138185 rs17076894

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
138185	Benign/Likely benign	criteria provided, multiple submitters, no conflicts	2	Microcephaly 1, primary, autosomal recessive; Clear cell carcinoma of kidney; Gastric cancer; Uterine corpus endometrial carcinoma; Colon adenocarcinoma; Ovarian serous cystadenocarcinoma; Uterine carcinosarcoma; Malignant tumor of esophagus; Lung cancer; Cervical cancer	germline	7	Feb 02, 2026	clinvar