CBL NM_005188.4(CBL):c.1111T>C (p.Tyr371His)

CI-VAR-00006231Explore in graph →p.Tyr371HisNM_005188.4:c.1111T>CClinVar 13811 rs267606706

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
13811	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Noonan syndrome-like disorder with juvenile myelomonocytic leukemia; RASopathy; Juvenile myelomonocytic leukemia; CBL-related disorder; Cardiovascular phenotype; Pilocytic astrocytoma	germline/somatic	18	Sep 15, 2025	clinvar