Variant · Snv
FIG4 NM_014845.6(FIG4):c.1090A>T (p.Met364Leu)
CI-VAR-00022378Explore in graph →p.Met364LeuNM_014845.6:c.1090A>TClinVar 137375 rs2295837
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-24
- Retrieved
- Sep 29, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260929-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 137375 | Benign/Likely benign | criteria provided, multiple submitters, no conflicts | 2 | Charcot-Marie-Tooth disease type 4; Amyotrophic lateral sclerosis type 11; Charcot-Marie-Tooth disease type 4J; Charcot-Marie-Tooth disease; Thymoma; Cholangiocarcinoma; Acute myeloid leukemia; Adrenocortical carcinoma, hereditary; Uterine corpus endometrial carcinoma; Colon adenocarcinoma; Malignant lymphoma, large B-cell, diffuse; Colorectal cancer | germline | 15 | Feb 04, 2026 | clinvar |