Variant · Snv
DOCK8 NM_203447.4(DOCK8):c.2295C>T (p.Ser765=)
CI-VAR-00022342Explore in graph →p.Ser765=NM_203447.4:c.2295C>TClinVar 137138 rs12348944
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-06
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260908-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 137138 | Benign | criteria provided, multiple submitters, no conflicts | 2 | Combined immunodeficiency due to DOCK8 deficiency; Ovarian serous cystadenocarcinoma; Hepatocellular carcinoma; Acute myeloid leukemia; Nonpapillary renal cell carcinoma; Uterine corpus endometrial carcinoma; Colon adenocarcinoma; Sarcoma; Gastric cancer; Lung cancer; Cervical cancer | germline | 8 | Feb 02, 2026 | clinvar |