ATM NM_000051.4(ATM):c.1027_1030del (p.Glu343fs)

CI-VAR-00021731Explore in graph →p.Glu343fsNM_000051.4:c.1027_1030delClinVar 135731 rs587780612

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
135731	Pathogenic	criteria provided, multiple submitters, no conflicts	2	Ataxia-telangiectasia syndrome; Hereditary cancer-predisposing syndrome; Familial cancer of breast; ATM-related disorder	germline	20	Jan 20, 2026	clinvar