MUTYH NM_001048174.2(MUTYH):c.1063del (p.Ala357fs)

CI-VAR-00021373Explore in graph →p.Ala357fsNM_001048174.2:c.1063delClinVar 134860 rs587778536

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
134860	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Carcinoma of colon; Hereditary cancer-predisposing syndrome; Familial adenomatous polyposis 2; Familial colorectal cancer; MUTYH-related disorder; Gastric cancer; Colorectal cancer	germline	39	Mar 30, 2026	clinvar