Variant · Snv
ZNF335 NM_022095.4(ZNF335):c.3187C>A (p.Arg1063=)
CI-VAR-00020524Explore in graph →p.Arg1063=NM_022095.4:c.3187C>AClinVar 130802 rs11905235
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-06
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260908-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 130802 | Benign/Likely benign | criteria provided, multiple submitters, no conflicts | 2 | Microcephalic primordial dwarfism due to ZNF335 deficiency; Uterine corpus endometrial carcinoma; Malignant lymphoma, large B-cell, diffuse; Uterine carcinosarcoma; Melanoma; Cervical cancer; Uveal melanoma; Thymoma; Cholangiocarcinoma; Colon adenocarcinoma; Colorectal cancer; Sarcoma; Gastric cancer; Acute myeloid leukemia; Hepatocellular carcinoma; Malignant tumor of esophagus; Nonpapillary renal cell carcinoma; Adrenocortical carcinoma, hereditary | germline | 7 | Feb 01, 2026 | clinvar |