Variant · Snv
TERT NM_198253.3(TERT):c.-124C>T
CI-VAR-00201418Explore in graph →NM_198253.3:c.-124C>TClinVar 1299388 rs1242535815
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-06
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260908-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 1299388 | Conflicting classifications of pathogenicity | criteria provided, conflicting classifications | 1 | Melanoma, cutaneous malignant, susceptibility to, 1; Malignant tumor of urinary bladder; Dyskeratosis congenita, autosomal dominant 2; Neoplasm; Sertoli-Leydig cell tumor; oligodendroglioma, 1p 19q codeleted; Desmoplastic small round cell tumor; Malignant glioma; Metastatic melanoma; Medulloblastoma WNT activated; Adenocarcinoma of the large intestine; Medulloblastoma SHH activated; Diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype; Juvenile type testicular granulosa cell tumor; Diffuse midline glioma, H3 K27M-mutant; Calcifying nested epithelial stromal tumor of the liver; Atypical teratoid rhabdoid tumor; Neuroblastoma; IDH-wildtype glioblastoma; Hepatosplenic T-cell lymphoma; Ovarian sex cord-stromal tumor; Squamous cell carcinoma of the skin; Pleomorphic xanthoastrocytoma | germline/somatic | 9 | Sep 01, 2025 | clinvar |