SDHB NM_003000.3(SDHB):c.268C>T (p.Arg90Ter)

CI-VAR-00006113Explore in graph →p.Arg90TerNM_003000.3:c.268C>TClinVar 12778 rs74315366

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
12778	Pathogenic	criteria provided, multiple submitters, no conflicts	2	Pheochromocytoma/paraganglioma syndrome 4; Hereditary pheochromocytoma and paraganglioma; Hereditary cancer-predisposing syndrome; Gastrointestinal stromal tumor; Pheochromocytoma; Carney-Stratakis syndrome; Von Hippel-Lindau syndrome; Inherited phaeochromocytoma and paraganglioma excluding NF1	germline	17	Aug 06, 2026	clinvar