TERT NM_198253.3(TERT):c.1234C>T (p.His412Tyr)

CI-VAR-00006103Explore in graph →p.His412TyrNM_198253.3:c.1234C>TClinVar 12730 rs34094720

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
12730	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications	1	Pulmonary fibrosis and/or bone marrow failure, Telomere-related, 1; Aplastic anemia; Autosomal recessive dyskeratosis congenita 4; Dyskeratosis congenita, autosomal dominant 2; Dyskeratosis congenita; Acute myeloid leukemia; Melanoma, cutaneous malignant, susceptibility to, 9; Idiopathic Pulmonary Fibrosis	germline	19	Jun 01, 2026	clinvar