PALB2 NM_024675.4(PALB2):c.1050_1053del (p.Thr351fs)

CI-VAR-00019116Explore in graph →p.Thr351fsNM_024675.4:c.1050_1053delClinVar 126586 rs515726060

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
126586	Pathogenic	criteria provided, multiple submitters, no conflicts	2	Hereditary cancer-predisposing syndrome; Familial cancer of breast; Malignant tumor of breast; Fanconi anemia complementation group N; Pancreatic cancer, susceptibility to, 3; PALB2-related disorder	germline	14	Dec 29, 2025	clinvar