HNF1B NM_000458.4(HNF1B):c.494G>A (p.Arg165His)

CI-VAR-00006093Explore in graph →p.Arg165HisNM_000458.4:c.494G>AClinVar 12647 rs121918675

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
12647	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Renal cysts and diabetes syndrome; Maturity-onset diabetes of the young; Type 2 diabetes mellitus; Nonpapillary renal cell carcinoma	germline	16	Jun 08, 2026	clinvar