HNF1B NM_000458.4(HNF1B):c.826C>T (p.Arg276Ter)

CI-VAR-00006090Explore in graph →p.Arg276TerNM_000458.4:c.826C>TClinVar 12640 rs121918672

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
12640	Pathogenic	criteria provided, multiple submitters, no conflicts	2	Renal cysts and diabetes syndrome; Autosomal dominant medullary cystic kidney disease with or without hyperuricemia; Type 2 diabetes mellitus; Nonpapillary renal cell carcinoma; Maturity-onset diabetes of the young; HNF1B-related disorder	germline	12	Jan 06, 2026	clinvar