Variant · Snv
HRAS NM_005343.4(HRAS):c.34G>A (p.Gly12Ser)
CI-VAR-00006082Explore in graph →p.Gly12SerNM_005343.4:c.34G>AClinVar 12602 rs104894229
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-24
- Retrieved
- Sep 29, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260929-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 12602 | Pathogenic | reviewed by expert panel | 3 | Costello syndrome; Myopathy, congenital, with excess of muscle spindles; EPIDERMAL NEVUS WITH UROTHELIAL CANCER, SOMATIC; Nevus sebaceous; RASopathy; Wooly hair nevus; Rhabdomyosarcoma; Lip and oral cavity carcinoma; Noonan syndrome and Noonan-related syndrome; Cardiovascular phenotype; HRAS-related disorder; Noonan syndrome 1; Epidermal nevus; Embryonal rhabdomyosarcoma; HRAS-related disorders; Fetal anomalies with a likely genetic cause | germline/somatic | 44 | Apr 03, 2017 | clinvar |