TP53 NM_000546.6(TP53):c.1010G>A (p.Arg337His)

CI-VAR-00006042Explore in graph →p.Arg337HisNM_000546.6:c.1010G>AClinVar 12379 rs121912664

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
12379	Pathogenic/Likely pathogenic/Pathogenic, low penetrance	criteria provided, multiple submitters, no conflicts	2	ADRENOCORTICAL CARCINOMA, PEDIATRIC; Hereditary cancer-predisposing syndrome; Li-Fraumeni syndrome; Breast neoplasm; Li-Fraumeni syndrome 1; Squamous cell carcinoma of the head and neck; Adrenocortical carcinoma, hereditary; Hereditary breast ovarian cancer syndrome; Gastric cancer; TP53-related disorder; Ovarian cancer; Neuroblastoma	germline/somatic	31	May 28, 2026	clinvar