Variant · Snv
HERC1 NM_003922.4(HERC1):c.7815G>A (p.Leu2605=)
CI-VAR-00198620Explore in graph →p.Leu2605=NM_003922.4:c.7815G>AClinVar 1218561 rs145406028
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-14
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260915-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 1218561 | Benign/Likely benign | criteria provided, multiple submitters, no conflicts | 2 | Uveal melanoma; Colorectal cancer; Ovarian serous cystadenocarcinoma; Sarcoma; Gastric cancer; Thyroid cancer, nonmedullary, 1; Thymoma; Melanoma; Hepatocellular carcinoma; Lung cancer; Cervical cancer; Familial cancer of breast | germline | 4 | Feb 01, 2026 | clinvar |