Variant · Snv
TSEN54 NM_207346.3(TSEN54):c.1313G>A (p.Arg438Gln)
CI-VAR-00198365Explore in graph →p.Arg438GlnNM_207346.3:c.1313G>AClinVar 1210718 rs200228117
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-14
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260915-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 1210718 | Conflicting classifications of pathogenicity | criteria provided, conflicting classifications | 1 | Inborn genetic diseases; Pontocerebellar hypoplasia type 4; Pontocerebellar hypoplasia type 5; Pontocerebellar hypoplasia type 2A; Gastric cancer; Colorectal cancer; Thyroid cancer, nonmedullary, 1; Malignant tumor of urinary bladder; Malignant tumor of esophagus; Familial cancer of breast | germline | 7 | Feb 25, 2026 | clinvar |