Variant · Snv
BNC2 NM_017637.6(BNC2):c.1240C>G (p.Leu414Val)
CI-VAR-00018579Explore in graph →p.Leu414ValNM_017637.6:c.1240C>GClinVar 120228 rs148873573
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-14
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260915-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 120228 | Benign | criteria provided, multiple submitters, no conflicts | 2 | Hypotension; BNC2-related disorder; Uveal melanoma; Malignant tumor of esophagus; Germ cell tumor of testis; Cervical cancer; Clear cell carcinoma of kidney; Nonpapillary renal cell carcinoma; Lung cancer; Sarcoma; Ovarian serous cystadenocarcinoma; Thymoma; Thyroid cancer, nonmedullary, 1 | germline | 6 | Feb 01, 2026 | clinvar |