G6PC1 NM_000151.4(G6PC1):c.648G>T (p.Leu216=)

CI-VAR-00005992Explore in graph →p.Leu216=NM_000151.4:c.648G>TClinVar 12003 rs80356484

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
12003	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Glycogen storage disease due to glucose-6-phosphatase deficiency type IA; Hepatocellular carcinoma; G6PC-related disorders	germline	19	Jan 24, 2026	clinvar