Variant · Deletion

ORC1 NC_000001.11:g.52369378_52373625del

CI-VAR-00196953Explore in graph →ClinVar 1173067

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
1173067	Pathogenic	criteria provided, single submitter	1	Meier-Gorlin syndrome 1	germline	1	—	clinvar

Nomenclature

Record

Gene: ORC1
Type: Deletion
HGVS g.: NC_000001.11:g.52369378_52373625del
Assembly: GRCh38
Position: chr1:52369375-52373623
Ref / Alt: TGTACATCTCCCATATTGCAACACCTCCCTTTCCCAAAGATGTACCCATTATCCTAAATTTAGTGTTTATTATTCCTGAGCATTTCTATTTCTGTGTAGGTATCCTTAAGCAATACATAGTATTTTTTTTGCCAGCTTTTAAAAATTATATCATTGGTTACATACAGTGTAATTCTTCAACCTTTTTCTACTCAACCCTGTTTGTAAGCTTCACTCAAATTGACATGTATACTGTATCTAGTTAGCTGATTTTCATTTCTGTTATGATTCCATAGCATGAAAATAAGTCACTTTCCCAATGGCTTACCATTATAGAGTGCTATGAACTTTTTGTATATGACTCTTGGTGTACGTATGTGAATTTCTCTAGAGCATATACTTAGGAATGGAATTGCTGGCTGCATTAGTCAGGTTTCTCTAGAGGAACAGAACTAATAGGATATATATATATATATATGTGTGTGTGTGTGTGTATATATATATGTGTGTGTGTGTGTATATATATGTGTGTATATATATATATGTGTATATATATATATAGTCCCACAATAGGCTGTCTGCATGCTCTATTAACCATCACACTGGCTGATATGGTTTGGCTCTGTGTTCCCACCCAAATCTCATCTTGAATAGTAATCCCATAATCCCCATGTGTCCTGGGAGGCATCTTGTGGGAGGTAATTGAATCATGGTTTCCTTCATGCTGTTCTTGTGATAGGAGTGAGTTCTCACGAGATCTGATGGTTTTATAAGCATCTGGCATTTCCCCTGCTGGCACTCATTCTCTCTCCTGCTGCCCTGTGAAGAGGTGCCTTTCACCATGATTTTAAGTTTCCTGAGGGCTCCCCAGCCATGTGGAACTGTGAGTCAATTAAACCTCTTTTCTTTATAAATTACGCAGTCTCAGGTATTTCTTCATAGCGCGAGGACAGACTAATACACTGGCTCATACAATTTCTTGCATTTCCTAGGCTAAGATTCACCAAATAATCTTCAAAAGTCATTCCACCTCCATCAGCAGGGTATTGGGGTCCCAGTTGTTCTGTGTAACCATAGAAAGGTTTTCTAATAGATGTGAAATGGTTTTGGTTTGCATGCCTCTTTTACTGTTTCCATTTTCTTGGTCATTCGTGTTTCTTCTTTGGATGACTTATTTGTTATTTACCCATTTTTTTCTTTTTCCTTCTTTTTTTTTTCTGAGACAGTCTTGCTCTGTTGCCCAGGCTGGAATGCAGTGGCACAATCTTGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTTTTGCCTCAGCACCCCTGTAGCTGAGATTACAGGTGCACACCATCACCCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCGAGCTGGTCTCGAATTCCTGACCTCAGGTGATCTACCTGCCTTGGCCTCCCAAAATGCTGGGATTACAGGTATGAACCACTGTGCCTGGCTCATTTTTTCTTTTTCATTGCAGTTTTAAAAATATTGATATTGATCCTCAATCCATTATATGTAATTATAAATACATATGTGAATATAGAAATACATATTTTTGCTAAATGATTTGAGAATGAGTTGCAGACATAATACATCACTTATAAATATTTCATTATGAATCTCCTAAGAACAGCATTCTCCTACATAATCACAAATTTATCACGCTCGGGGAATTTAACACTTACAAAATACTTCTGTCTAATACATAGTTAATAATGTTTATAATTGTTTATATTTCCTAAATCCAGGACCCAGTCAAGGTTTATATAGTGCATTTAGCTCTCATGTCTCTATTCTCCTTTGGTGTAGAATAGTTCCTCCATGTTTTGTGTTTTTTTTCTTGTGATATTAGTATTTTCAATGAGTTGAACAGCTGCTTTGCAGAGTTTCTCCCTAAATTTAGATTTGTCTGATAATTTTCTCATCAGTAAATTTAGGACAAGCATTTCTGACAGGACTAGTACACGGGTGGGGCTGTTTTTTTTCAGTACCTCATATTAGGTTTTATTTATTTTTTTCAGACGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAATGGTGTGATCTCAGCTCACTGCAACCTCTGCCTCCTGGGTGGGTTCAAGCAATTCTCCTGACTCCCAAGTAGCTGGGACTACAGGTGACACCACCACGCCAGACTAATTTTTGCATTTTTAGTAGAAACGAGATTTCACCATATTGATCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTTGGCCTCCCAAAGTGTTGGGATTACCGGCATGAGCCACCCACGCCCAGCCTCAGTACTTCATGAGGTTTTAGATGTTCATTGCCTGTTGTTGGTTTCCATATAAATATTAGAATTAACTGCAAAGTCATACAAGAAACCTTGCCAAGATTTTGATTGGAATTGATTTCTATCTAGAGATTACTTGCATCTCTTTATTAGACTTATTCCTAGGAGACGGACATGGTGGCCCACACCTGGAATCCCAGCTACTTAGGAGGCTGAGGCAGGATTACTTGAACCCAGGAGGTTAAGGCTGGAGTGAGCTATGATCCATTACTGCATTCCAGCCTTGGTGACAGAGGGAAAAAATAAATAAATAAATAAATATTTAAATCAATTTATTTCTAAGTACCTTATATTTTCTGTGACATATAAATCTTTTGTATTTAAAGGTTTGTTTTGTTTTTATGGTAAATGGTACCTTTGTAAAAATTACACTTTCTAGCTATTTGTGGCTAGAGATTACTTATGATTTATATTATTTCCAGTAGTTCCTTTTTTATAAACTATATTTTATTTATTTATTTATTTATTTATTTTTGAGACGGAGTTTCACTCTGTCGCTCAGGCTGGAGTGCAGTGGCGCGATCTCAGCTCACTGCAAGCTCCGCCTCCCGGGTTCATGCCACTCTCCTGCCTCAGCCTCCCGAGTAGCTGGACTACAGGCGCCCGCCACCACAACTGGCTAATTTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGCCCCTGGCCTAAATTTTATTTATATTATTTGAAACTTAAGACAGATAATGACATACAGTGAAAAGTCCTCCTCTAACCCCTAACCCTGGCCATCTGATTCTTTCCATCTGATTCTTTCCAGAGGTAATCAGTGTAACCAGTTTTTTGCATACTCTCCCAGAACTATTTTATATAGATACAAGTAAATCGTGTACTTATATTTTATATATGTTAGCATTAAATAAATGGCAGGCCTAGTAACAGAAATAAAAGTCACATGGAAGGACTATTGTAGGAAGGACAGTTTGGTTTCATAATCAGATGTTTGTAATGATTATAATGTAATAACTTCACAAACACTCAGGAAAAAGCAAATTATTTAATGGAAAATTCCAAAATACATGAGAGCCATTTCCATTCAATATACTTTGTTACAACAATTCCATGTACTTCCAAAATCAGATGCTTTGTAGACTAGCTTGGCAACATGGTGAAGCCCTGTCTCTACAAAAAATCAGCTGGGCATGGTGGCATGTGCCTGTAGTTTCAGCCACCTGGGAGGATGAGGTTGGGGGGTCACCTAAGCCTGAGAAGTCAAGGCTGCAGTGAGCCATGATCGTGCCACTGCACTCCAGCCTGGGCGACAGAGCAAGACCCTGTCTCAAAAAACAAAACCCAGCAAGACCCCAGTCTTTTAACTTGTGAAGCCCCTTTACTCGTCTTTCAGCGCATACAGCACATCATCCTGGCTGACGTTGAGCCGCACCCGAAGGAGCAGATCGTTCCTGCTGGGCTCCACAAGCAGGAGGCGACAGGAGCCCAGGTGAGAACACACGGCCATGGTCTCTGACATGGTGGGGTACGGCAGTCCCTCCATTCTGCACAGTGCCACATGTTGACTATATATCTAGACACAAATAGCAAGGCAAAGGTTAAGAGGAAATACAATCCTGGGGCTTTTTCTGTTCCTTTCTTTCTTCATTTGGGAAAATCAGACACATGGCCCCCAGGATATCAAACACTCCAGAAGGCATCAGTTGGTGCCCCAGTGGTACACAAAATGCAGAGGCAGAATGGAATGCTAGCCTTGGAATCAGAAAACAGCAGGCCCGAATCCTGGTGCTACCATTTACCTAAATATGTAGACCTGGCCAA → T