RPS6KA3 NM_004586.3(RPS6KA3):c.2186G>A (p.Arg729Gln)

CI-VAR-00005971Explore in graph →p.Arg729GlnNM_004586.3:c.2186G>AClinVar 11658 rs28935171

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
11658	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Coffin-Lowry syndrome; Intellectual disability; Inborn genetic diseases; Nonpapillary renal cell carcinoma; Thyroid cancer, nonmedullary, 1; Intellectual disability, X-linked 19	germline	7	Mar 23, 2025	clinvar