Variant · Snv
EPRS1 NM_004446.3(EPRS1):c.1256A>G (p.Tyr419Cys)
CI-VAR-00196010Explore in graph →p.Tyr419CysNM_004446.3:c.1256A>GClinVar 1165014 rs114015346
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-14
- Retrieved
- Sep 15, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260915-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 1165014 | Benign | criteria provided, multiple submitters, no conflicts | 2 | Cholangiocarcinoma; Malignant tumor of esophagus; Melanoma; Acute myeloid leukemia; Uterine corpus endometrial carcinoma; Clear cell carcinoma of kidney; Thyroid cancer, nonmedullary, 1; Nonpapillary renal cell carcinoma; Cervical cancer | germline | 3 | Jan 24, 2026 | clinvar |