Variant · Deletion

CHEK2 NM_007194.4(CHEK2):c.908+1540_1095+330del

CI-VAR-00184539Explore in graph →NM_007194.4:c.908+1540_1095+330delClinVar 1077093

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
1077093	Pathogenic	criteria provided, single submitter	1	Carcinoma of pancreas; TUMOR PREDISPOSITION SYNDROME 4, BREAST/PROSTATE; Familial cancer of breast	germline	4	Mar 28, 2024	clinvar

Nomenclature

Record

Gene: CHEK2
Type: Deletion
HGVS c.: NM_007194.4:c.908+1540_1095+330del
Assembly: GRCh38
Position: chr22:28696570-28701965
Ref / Alt: GTTGGTCTCAAACTCCTGACCTCAGGTGATCTGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCATACCCAGCCCACTCGTCCATTTAGACCCCTCCTCTCTCTCTAAGCACAAAGGTCACTTGTACACAACAGAGCTCAATAAATGCTCATTCGAATCTGGATAAGAGCAGTATCACCTGATCTCTAAAATAATTGGTAACAGTGAAAGGGTCAGATTCTCATCCTTTTTACGCTCCCACTTTTTATTTGAGGAATTAAAAGTTTCTGAACAAGAATCTACAGGAATAGCCACATACAGAATGCCAATTTCTTACCTTTATAAGACAGTCCTCTTCTTGAGATGACAGTAAAACATTCTCTGGCTTTAAGTCACGGTGTATAATACCGTTTTCATGAAGGTACTACACAGAAAGGCAGGCATGACCCTCAGATTCATGCAGTAGATACTTAAGTAGAATCAAAGTTACCAACACACACATCTCACAGCTGGGTGAAACCGTAAGCCGTGATACACACAACCATATTCTCCAAAATCATAGAAAACTGTTGGGGTAAAGTTTACAAATTTGTTTGAGAAGATCTTTAAAAAGCAGGGAAATGAAAAAAGCAACTTAGAACAATTAACCTTTCATTTCACTTTAAGATAATAAACAACTCTTCACACAGCAGAAATGTAAGGTGTCAATTTCAATAAAAATTCAAATGGGTAACAGAAAATGTTTTGAGAACATACCAAATAAACACAAAAATTCCACCAAAATGATATATTTGGTTATTGCAGTCCTGAGAATATTTTTAAAGGGAACCTATACAAATATATATTTGTAAATATCTATTTATGTGATACAAATATATATCTGTTTATGTGAGTTAACCTATTCCTCAATGCAAAGACTTTGTCTTTGAAAAAACTATTGTCTGAAATAGCATATAAAAATGAACAAACACCAACATACTATGCCATATTTCTTTTCTTTTCTTTTCTCTTTTTTTTTTTTCTTGAAACAAGGTCTCACTCTGTCCCCCAGGCTGAAGTGCAGTGGCACCATCTTAGCTCACTACAGCCTCAACCTCCTCAGCTCAAGTGATCCTCCCACCTCAGCCTCATGAGTAGCTAGGACCATAGGCACAAAGCATGCCACTTCAACCAGCTAACTTCTTTATTTTTTTGTAGAGACGGGATCTCACAATGTTGCCCAAGCTGGTCTGGAACTCTTGGGCTAAAGTGACCTTCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATCAGCCACCCTGCCTGGCCATATTTTTTTAGGAAACAAAATTTTCACATATCCACAAACTGTACTCAATTCATGTTAATATTCTTGGTTACTCAATATAAATAAATGGAATAAACCAATAAGGGAGCAATACACTGAGTAGGTGACAGCTACCATTAAAAAGGGCTTGCGTTGTACCCCATAAACATGTACACCTACTATGTGCCCACAAAAATTAAAATTAAAATTAAATTTTTTTTTTAAAAAGGCTTGTGGGCGGGCACGGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGCTCAAGGCAGGCGGATAGTTTGAGGTCAGGAGTTTCAGAACAGCCTGGCCAACATGGTGAAACCCTATCTTTACTAAAAAAAAAAAAAAAAAAATTAGCTGGACATGGTGGCAGGCACCTGTAATCCCAGCTACTGGGTAGGCTGAGGCAGGAGAATCACTTGAACCCGAGGTGGAGGTTGTAGTGAGCCGAGATCGTGCCATTGGACTCCAGCCTGGGCGACACAGTGAGACATCATCTCAAAAAAAATAAACAAATAAAAATAAATTTAAAAGGCTTGTGTTTATGGGCTTCAATCTTCTCTGGATGTCCCTCTGGGTTAGAACAAAAATTTTTTGCAAAATCTTTACTGGGAAATGGATCTGGTGAAACCTCCAGGGAGGGCAAACCTAGGTAGATCAATCATAAAAAAATTTCTCTCGATCCTCACTCTGTACAAGGATTGCTCCCAATCACTGCATTTCCTGCAAGGAGTGGGTTTTCAAGAAGAGACTGGAAGGGAATGGCCACAACCACATTTGGTCTGGGAAATGGTGATGTTCCTCAAAGCAAGTGCCACCAGCTATTCTTTCATCTAACACCTACTGAATAGAGATGGCTATGTGCATTCCCTGCCGGCCCGCCCACTGCAGCGAACAGGATGCTGCACCTGAAGGGAAACACCTAGTTCTGAGCCATGGGGGACCAACCCATCTGTCACAATCATCACAACTTGCAGCTCTGCCCTCAAACCTGCCCAGCTCCCACTCTGAGTTAAGAGAGACTTCTACAAGGATCAAGCAGAACTAAAGAACTAATGATCAAGACCCCTCCAGAAATACCTCCAAGCTAAAGATAGGCGACATAGGGCCATGTTATCTCTTTTTTTAAAGACAGAGCATCATTCTGTTGCCTAGACTGGAGCGCAGTGGCATGACTGTGGCTCACTGTAGCCTCAACCTCCCAGGCTCAAGCCGTCCTCCCAACTCAGCCTCCAGAGTGGCTAAGACCACAGGTGCCCGCCACCATGCCTGGCTATTTTTATTTTTTGTAGAGATGGGGGTCCCATTATATTGCCCAGGCTGGTCTTAAACTCTTGGGCTCAAGTGATCCTCCTGCCTTGGCCTCTCAAAGTGCTGGGACTACAGGCGTGAGCCACTATGCCTGGTCTATTTATTTCTTTAATTCCCTTTCTTACTTTCTCTTAAGCTACACAGTGAGAGCTTTTTCTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCACTCTGTCCCCAGGCTGGAGCACAGTGGCATGATCTCAGCACACTGCAACCTCCACCTCCCAGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACGCAACACTACACCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACTATGTTGGTCAGGATGGTTTTGATCTCTTGACCTCGTGATCCGCCCGCTTGGCCTCCCAAAATGCTGGGATTATGGGCATGAACCACCGCGCCTCGCCAGTGAGAGCTTTTTCATCTCAGTGAAAGGAGTAGGACATTTTTGCCAAGAAGAGAACAGCAAACACACAGATTCTCTTCTGAGTTTTAATCCACGGTCCCTCGATTTCTGCCTAATTCAGGGAGTAATTCAACTAAAAGAAAGGCAGCTGTCAAAAGAATTGAGGGCTTCTTTTACCTGCACAGCCAAGAGCATCTGGTAAAAATAGAGCTTGCAGGTAGCTTCTTTCAGGCGTTTATTCCCCACCACTTTGTCAAACAGCTCTCCCCCTTCCATCCTGAAACACAAAGGCAAGGCAAGGGGTTCATTCCTGGGGGAAAACGCACTTGGACAGAAGACAATAAAACAACAAAACAAATTCATTAAGACAAGCAAACAGTTGACATTTTTATTCACTTTTGACTCTCATTTTTAAAACTAATAAGGTTTATTCACAATCAGATGTCCCAGTTGGAAACTAAGGAATGAGATGAAAGGATTGGGCATTGGAGGCACCTGGGGAACTTTAAAAAATCCAATTCAGTAGCTTGGAAGTGGGGCCCAGGAGTTGCTTTTTTTTTTTTTTTTTTGAGACAGAGCCTCGCTCTGTCACCCAGGTTGGAGTGCAGTGGTGCGATCTTGGCTCACTGCAACCTCCGCTTCCCAGGTTCAAGTGATTCTCATGCCTTAGCCTCCCAAGTAGCTGGGATTACAGGTATGCACCACCATGCCCGGCTAATTGTTGTATTTTTTTTAGTAGAGACAAGGTTTTGCCATGTTGGCCAGGTTGGTCTCAAATTCCTGGCCTCAAGTGATCTGCCCACTTTGCCCTCCCAAAAGTGCTGGGATTACAGGCATAAGCCACCGCACCCAGTCAGGAGTTTGCATTTTTATCACACACCACAGATGATTCTGAGACTGATGTAGAAGAGCAAACAGAATTTTACAAACAGACAACCAGGATCTGAACCCTAACTCTACCATTTCCCAGCTTTTGGACTTTGGGAAAGCTATTTAACCTCTCTCAGCTTGTTTCTACCACTTAAAAAATGGGGATGATACCATCTACCTTGATGGTTGTTATAAAAATTAAGAGATGGCTGATGTAGGAAAAGCTCCTGGCACAGGTGCTTGGCAAGGTTATTCCTTTATTTATTTATTTATTTTGAGACAGAGTTTCGCTCTTATTGCCCAGGCTGGAATGCAATGGCGCAATCTTGGCTCACCGCAACCTCCACCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCATTCACCATCATGCCCGGCTAATTTTGTATTTTTAGTAGAGATGCGGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCTGCTCCCCTCGGCCTCTCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGCTCTGTATTATCACTTTTATTAACTGTGTTAACTGGATTCAGTCAGGTAACAATCTCCTATTTGATAGCAGCAGATCCACAAGGGGCTCCAGGCTCTCCCAGTGCTGTGATCAGGGGTGATCAGGGGTGTTTTTACCATAGTCTTTTTTCTTTTTTCTTATGTTTTTTGAGACAGTCTTGCTCTGTCCATCACGGCTCACTACAACCTCCGCCTCCCAGGTTCAAGCGATTCTCCACGCCTCAGCCACCCAAGGAGCTGGGACTACAAGCACATGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGGCCTCAAGGGATCCGCCCACCTCAGCCTCTCAAAGTCCTGGGATTACAGGTGTGAGCCACCACACCCAGCCTGTTGTCTATACAGTCTTAATGATCACCCTGCATAGATACGATTTGCCAACCAGGAGCAAAGCATTCTGTGCCTGCCACAATAGCTGCTCCCAGAAACACTTAATATTTATGCAGGAGCAGATATCAAGACAGGCATCTTCCAGAAATGAGACAGGAAGTTATTCTGATTACACCAAATAACACAAGACATTATCGCCACTGAAATAAACTACCAAGACACTGAAAGATACTCAGGTGCCACCATGCAACCTGGTCCTGGATTGAAAGGACCCGCATAGAAAGTCCTACCCAGGTAGATATTTCAGAGTAGAGCTGTCCCTCAGTATCCATGGGGAATTGGTTCCAGGAGCTCTCTCAGAGACCAAAATCCATTATGCTCAAGCCCTTTATATAAAATGGCGTAAGATTTGCATATAATCTATGTATATCATCCCATATACTATTTTTTTTTTT → G