DARS2 NM_018122.5(DARS2):c.492+2T>C

CI-VAR-00005209Explore in graph →NM_018122.5:c.492+2T>CClinVar 1062 rs142433332

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
1062	Pathogenic	criteria provided, multiple submitters, no conflicts	2	Leukoencephalopathy with brain stem and spinal cord involvement-high lactate syndrome; Gait ataxia; Gait imbalance; Dysmetria; Inborn genetic diseases; Ovarian serous cystadenocarcinoma; Charcot-Marie-Tooth disease, axonal, type 2LL; DARS2-related disorder	germline	23	Jan 26, 2026	clinvar