CDKN2A P81T

CI-VAR-00003413Explore in graph →NP_000068.1:p.Pro81ThrNM_000077.5:c.241C>AClinVar 629992 CIViC 3384

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
CDKN2A P81T	(functional)	Functional	D	Supports Loss Of Function	3	submitted	EID9424 Melanoma-associated germline CDKN2A mutations were assessed for functional effects. Amino acid conservation between human and nine other species showed that proline 81 is highly conserved and changes … (full text at CIViC) PMID 19260062 · Kannengiesser et al., 2009 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.