Variant
CD274 v242
CI-VAR-00005070Explore in graph →CIViC 3508
Curated evidence
Evidence by cancer (1 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 30872362
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Lung Non-Small Cell Carcinoma1 | ||||||||
| CD274 v242 | Atezolizumab + Avelumab + DurvalumabSubstitutes | Predictive | E | Supports Resistance | 4 | submitted | EID9695In an in vivo study, mice injected with v242 show significantly reduced survival compared to mice expressing WT (p < 0.001) when treated with anti-PD-L1 antibody. Moreover mixing only 1% MC38 cells wi… (full text at CIViC) PMID 30872362 · Gong et al., 2019 · Open in CIViC | civic |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available
No ClinVar interpretation attached to this variant.