BRCA2 P655R

CI-VAR-00003384Explore in graph →CIViC 2990

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Breast Neoplasm1
BRCA2 P655R	(prognostic)	Prognostic	D	Supports Better Outcome	4	submitted	EID8037 Based on the ability of a Brca2 construct with P655R to rescue the lethality of Brca2-deficient mES cells and its effects on sensitivity to DNA-damaging agents, homologous recombination and genomic in… (full text at CIViC) PMID 22678057 · Biswas et al., 2012 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.