Variant · Snv
BRCA1 C64Y
CI-VAR-00000355Explore in graph →NP_009225.1:p.Cys64TyrNM_007294.3:c.191G>AClinVar 54400 CIViC 1239 rs55851803
Curated evidence
Evidence by cancer (0 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
Data not yet available
No curated evidence item references this variant yet.
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
clinvarProvenance
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-24
- Retrieved
- Sep 29, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260929-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 54400 | Pathogenic | reviewed by expert panel | 3 | Hereditary breast ovarian cancer syndrome; Breast-ovarian cancer, familial, susceptibility to, 1; Hereditary cancer-predisposing syndrome; Pancreatic cancer, susceptibility to, 4; BRCA1-related cancer predisposition; Inherited prostate cancer; BRCA1-related disorder | germline | 31 | Jun 11, 2024 | clinvar |