BRAF V600_S605delinsDV

CI-VAR-00004585Explore in graph →CIViC 3241

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
BRAF V600_S605delinsDV	(functional)	Functional	D	Supports Gain Of Function	3	submitted	EID8966 this complex in-frame mutation involving amino acids V600-S605 has been found in a stage III multicentric follicular variant PTC. Bioinformatic modeling was performed to predict its impact on BRAF act… (full text at CIViC) PMID 18426810 · Barzon et al., 2008 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.