ARID1A Mutation

CI-VAR-00002750Explore in graph →CIViC 4806

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Diffuse Large B-Cell Lymphoma1
ARID1A Mutation	(oncogenic)	Oncogenic	E	Supports Oncogenicity	4	submitted	EID11907 This study sequenced 73 DLBCL tumors (34 with matched constitutional DNA) and reported 322 genes they deemed recurrently mutated. Only genes that have been confirmed by other similar studies were adde… (full text at CIViC) PMID 23292937 · Zhang et al., 2013 · Open in CIViC	civic
Unmapped disease1unmapped disease
ARID1A Mutation OR ARID1B Mutation	(functional)	Functional	B	Supports Loss Of Function	3	submitted	EID12642 Concurrent inactivating mutations in ARID1A and ARID1B were identified in 12 of 24 BRG1/INI1-intact dedifferentiated endometrial or ovarian carcinomas, with all co-mutated tumours showing complete los… (full text at CIViC)

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.