ABL1 I432T

CI-VAR-00002001Explore in graph →NP_005148.2:p.Ile432ThrNM_005157.5:c.1295T>CCIViC 1533

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Chronic Myeloid Leukemia, BCR-ABL1 Positive1
BCR::ABL1 Fusion AND ABL1 I432T	Bosutinib	Predictive	C	Supports Resistance	2	submitted	EID4562 In a retrospective study of 288 imatinib-resistant or -intolerant, Philadelphia chromosome BCR-ABL1fusion positive, chronic myeloid leukemia (chronic phase) patients, a patient with the I432T mutation… (full text at CIViC) PMID 21865346 · Cortes et al., 2011 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.