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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
61 stopped studies mapped to WHO Grade 3 Glioma and descendants · 82% state a reason
Over the 61 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00761280 | Efficacy and Safety of AP 12009 in Patients With Recurrent or Refractory Anaplastic…(SAPPHIRE) | Phase 3 | terminated | Sep 29, 2008 | Isarna Therapeutics GmbH | Unable to recruit the projected patient number. All analyses are descriptive, only. | Enrollment / accrual |
| NCT02055196 | Genetically Modified Stem Cells and Irinotecan Hydrochloride in Treating Patients With… | Phase 1 | withdrawn | Feb 5, 2014 | City of Hope Medical Center | New study written | Other (stated, no rule matched) |
| NCT01095094 | Ritonavir and Lopinavir in Treating Patients With Progressive or Recurrent High-Grade… | Phase 2 | terminated | Mar 29, 2010 | Case Comprehensive Cancer Center | Study did not meet its primary objective | Other (stated, no rule matched) |
| NCT01269411 | RO4929097 in Treating Patients With Recurrent Invasive Gliomas | Phase 1 | terminated | Jan 4, 2011 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00006773 | Bortezomib in Treating Patients With Recurrent Glioma | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00110032 | Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of… | Phase 1 | terminated | May 4, 2005 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00430079 | Use of EF5 to Measure the Oxygen Level in Tumor Cells of Patients Undergoing Surgery or… | N/A | terminated | Feb 1, 2007 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00734864 | Ph. I Dasatinib/Protracted Temozolomide in Recurrent Malignant Glioma | Phase 1 | withdrawn | Aug 14, 2008 | Annick Desjardins | Study drug supplier withdrew support for the study. Study was withdrawn from the Duke IRB. | Other (stated, no rule matched) |
| NCT00272870 | Treatment of Newly Diagnosed Brain Tumors With Chemotherapy and Radiation Using Cells… | Phase 1 | terminated | Jan 9, 2006 | Children's Hospital Medical Center, Cincinnati | Slow accrual; drug availability | Drug supply |
| NCT00062504 | Phase 2 Trial Using Talampanel in Patients With Recurrent High Grade Gliomas | Phase 2 | terminated | Jun 12, 2003 | Teva Branded Pharmaceutical Products R&D, Inc. | not stated | Not stated |
| NCT00243490 | Photodynamic Therapy in the Treatment of Malignant Intracranial Tumors | Phase 2 | withdrawn | Oct 24, 2005 | National Taiwan University Hospital | The Trial could not get permit from Department of Health, Taiwan; Furthermore, no research fund… | Funding |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Nov 14, 2014source: clinicaltrials