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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,358 stopped studies mapped to Non-Hodgkin Lymphoma and descendants · 89% state a reason
Over the 1,358 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00704691 | Lenalidomide Therapy for Patients With Relapsed and/or Refractory, Peripheral T-Cell… | Early Phase 1 | terminated | Jun 25, 2008 | University of Alabama at Birmingham | Closed due to futility with only 1 patient accrued | Efficacy / futility |
| NCT00171925 | Therapy With Zoledronic Acid in Patients With Multiple Myeloma Stage I | Phase 3 | terminated | Sep 15, 2005 | Novartis Pharmaceuticals | Recruitment in study could not be reached after 8 yrs of recruiting | Enrollment / accrual |
| NCT00366106 | Alternative Schedule of Velcade/Dexamethasone Plus Doxil for Patients With Multiple… | Phase 2 | terminated | Aug 18, 2006 | Accelerated Community Oncology Research Network | Study was closed to enrollment when it became clear that enrollment was too slow to complete full… | Enrollment / accrual |
| NCT01452334 | Safety Study of Anti-Programmed Death-Ligand 1 in Hematologic Malignancy | Phase 1 | withdrawn | Oct 14, 2011 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00475332 | Study to Treat Relapsed Follicular Non-Hodgkin's Lymphoma With Radiation and Bexxar | Phase 2 | terminated | May 21, 2007 | University of Florida | PI left our institution | Investigator |
| NCT01175278 | Vertebral Augmentation With Kyphoplasty vs Nonsurgical Mgmt for Vertebral Body… | N/A | withdrawn | Aug 4, 2010 | H. Lee Moffitt Cancer Center and Research Institute | No enrollment | Enrollment / accrual |
| NCT00432419 | Therapeutic Intensification of HIV-associated Non-Hodgkin's Lymphoma by Peripheral Blood… | Phase 1 / Phase 2 | terminated | Feb 7, 2007 | French National Agency for Research on AIDS and Viral Hepatitis | only one patient enrolled | Enrollment / accrual |
| NCT00473551 | Anti-Third Party T Lymphocytes With Nonmyeloablative Stem Cell Transplantation for… | Phase 1 | terminated | May 15, 2007 | M.D. Anderson Cancer Center | Terminated due to slow accrual. | Enrollment / accrual |
| NCT00400764 | A Study of Dulanermin in Combination With Rituximab in Subjects With Follicular and Other… | Phase 1 / Phase 2 | terminated | Nov 17, 2006 | Genentech, Inc. | not stated | Not stated |
| NCT00712062 | Study of Pemetrexed to Treat Recurrent or Progressive Primary Central Nervous System… | Phase 2 | withdrawn | Jul 9, 2008 | University of Florida | Lack of accrual | Enrollment / accrual |
| NCT00107614 | DT PACE, Tandem Autologous Transplant, Maintenance Therapy for Waldenstrom's… | Phase 2 | terminated | Apr 6, 2005 | University of Arkansas | Terminated due to poor accrual. | Enrollment / accrual |
| NCT00573391 | Study of Multiple Myeloma Patients Relapsing or Progressing After Autologous… | Phase 3 | terminated | Dec 14, 2007 | University of Arkansas | low accrual | Enrollment / accrual |
| NCT00880867 | Intratumoral Poly-ICLC Plus Low Dose Local Radiation in Low Grade Recurrent B and T Cell… | Phase 1 | terminated | Apr 14, 2009 | Nevada Cancer Institute | Low enrollment | Enrollment / accrual |
| NCT01116128 | Dasatinib in Combination With Melphalan and Prednisone to Treat Relapsed and Refractory…(D-MP) | Phase 2 | terminated | May 4, 2010 | Fondazione EMN Italy Onlus | difficulty in enrolling patients | Enrollment / accrual |
| NCT00577668 | A Pilot Study of the Combination of Melphalan, Bortezomib, Thalidomide and Dexamethasone… | Phase 2 | withdrawn | Dec 20, 2007 | University of Arkansas | Poor accrual | Enrollment / accrual |
| NCT00216151 | Zoledronic Acid in the Management of Patients With Asymptomatic/Early Stage Multiple… | Phase 2 | terminated | Sep 22, 2005 | Hoosier Cancer Research Network | Study terminated due to low patient enrollment. | Enrollment / accrual |
| NCT01170052 | Bendamustine and Temsirolimus in Patients With Relapsed or Refractory Mantle Cell… | Phase 1 / Phase 2 | withdrawn | Jul 27, 2010 | Charite University, Berlin, Germany | insufficient enrollment | Enrollment / accrual |
| NCT00050687 | Safety and Pharmacokinetics of Orally Administered Gallium Maltolate in Various… | Phase 1 / Phase 2 | terminated | Dec 19, 2002 | Titan Pharmaceuticals | not stated | Not stated |
| NCT00651443 | Mechanism of Action of Galiximab in Subjects With Previously Untreated Follicular… | Phase 1 | terminated | Apr 2, 2008 | Biogen | A company's strategic decision to focus on areas whereit believes it can be competitive and decided… | Sponsor / business decision |
| NCT01116154 | Vorinostat and Lenalidomide in Treating Patients With Relapsed or Refractory Hodgkin… | Phase 1 | terminated | May 4, 2010 | City of Hope Medical Center | Sponsor withdrew support for the study | Other (stated, no rule matched) |
| NCT00386321 | Yt90 Zevalin and Combination Chemotherapy (Z-CHOP)in Treating Patients With Stage II,… | Phase 2 | terminated | Oct 11, 2006 | Chulalongkorn University | Participants are no longer being examined or treated. | Other (stated, no rule matched) |
| NCT00162500 | A Novel Vaccine for the Treatment of MUC1-expressing Tumor Malignancies | Phase 2 | withdrawn | Sep 13, 2005 | Hadassah Medical Organization | not stated | Not stated |
| NCT00136591 | A Phase 2 Study of Velcade™ in Subjects With Relapsed or Refractory Follicular B-Cell… | Phase 2 | terminated | Aug 29, 2005 | Lymphoma Study Association | An arm closed due to lack of efficacy | Efficacy / futility |
| NCT00775957 | Assessment of Hematopoietic Recovery Following Chemotherapy for Non-Hodgkin's Lymphoma | — | terminated | Oct 20, 2008 | University of Oklahoma | Terminated by institutional review board | Other (stated, no rule matched) |
| NCT00275262 | A Study to Evaluate the Ability of Lupron Depot to Enhance Immune Function Following Bone… | Phase 2 | terminated | Jan 11, 2006 | Abbott | not stated | Not stated |
| NCT00304590 | Study of XL999 in Patients With Multiple Myeloma | Phase 2 | terminated | Mar 20, 2006 | Symphony Evolution, Inc. | Study was terminated due to cardiac toxicities in the subjects | Safety / toxicity |
| NCT00161239 | LAMPP Trial for Peripheral and Cutaneous T-Cell Lymphoma | N/A | terminated | Sep 12, 2005 | University of Medicine and Dentistry of New Jersey | toxicity | Safety / toxicity |
| NCT00243763 | TKI258 in Subjects With Refractory or Relapsed Multiple Myeloma | Phase 1 | terminated | Oct 25, 2005 | Novartis | not stated | Not stated |
| NCT00471367 | Phase I, Open-label, Dose-escalation, Safety and PK Study of AZD4877 | Phase 1 | terminated | May 9, 2007 | AstraZeneca | Part B of the study was terminated early due to a lack of enrollment. | Enrollment / accrual |
| NCT00354822 | Fludarabine,Cyclophosphamide and Rituximab Followed by Zevalin for Non-Follicular…(Z0105) | Phase 2 | terminated | Jul 20, 2006 | A.O. Ospedale Papa Giovanni XXIII | Inability to recruit in time a sufficient number of patients | Enrollment / accrual |
| NCT00474188 | A Study to Evaluate Lenalidomide Combined With Dexamethasone in Relapsed or Refractory… | Phase 2 | terminated | May 16, 2007 | Celgene Corporation | Business decision | Sponsor / business decision |
| NCT00441025 | The Effectiveness of Alemtuzumab Combination With CHOP to Treat Patients Newly Diagnosed… | Phase 2 | terminated | Feb 27, 2007 | Mahidol University | a lack of a potential patient. | Other (stated, no rule matched) |
| NCT00547404 | Phase I Study for Safety and Efficacy of P276-00 in Subjects With Myeloma | Phase 1 | withdrawn | Oct 22, 2007 | Piramal Enterprises Limited | Not to expose the patients to subtherapeutic dose | Other (stated, no rule matched) |
| NCT00083564 | Study Comparing STR (Skeletal Targeted Radiotherapy) Plus Melphalan to Melphalan Alone,… | Phase 3 | terminated | May 28, 2004 | Poniard Pharmaceuticals | For business reasons | Sponsor / business decision |
| NCT00039754 | A Trial of Skeletal Targeted Radiotherapy Using Holmium-166-DOTMP in Patients With… | Phase 1 / Phase 2 | terminated | Jun 11, 2002 | Poniard Pharmaceuticals | business reasons | Sponsor / business decision |
| NCT00352742 | A Study of ATN-224 and Bortezomib in Patients With Multiple Myeloma | Phase 1 / Phase 2 | terminated | Jul 17, 2006 | Attenuon | not stated | Not stated |
| NCT00538096 | A Phase I Study to Evaluate Safety, Tolerability in Adults With Lymphoma | Phase 1 | withdrawn | Oct 2, 2007 | MedImmune LLC | Replacing this trial with a new trial. | Other (stated, no rule matched) |
| NCT00147485 | A Phase 1 Study Of An Intravenously Administered Cyclin-Dependent Kinase Inhibitor In… | Phase 1 | terminated | Sep 7, 2005 | Pfizer | See Detailed Description | Other (stated, no rule matched) |
| NCT00200668 | Comparison Between FDG-PET and MRI for the Assessment of Response to Intensive… | N/A | terminated | Sep 20, 2005 | Nantes University Hospital | not stated | Not stated |
| NCT00234481 | Safety Study of XL844 in Subjects With Chronic Lymphocytic Leukemia | Phase 1 | terminated | Oct 7, 2005 | Exelixis | Study closed due to slow enrollment | Enrollment / accrual |
| NCT00250861 | Trial of Outpatient Immunotherapy With Rituximab and Aldesleukin (IL-2) vs. Rituximab… | Phase 2 | terminated | Nov 8, 2005 | US Oncology Research | Study terminated due to lack of enrollment. | Enrollment / accrual |
| NCT00644306 | Comparison of Melphalan-Prednisone (MP) to MP Plus Thalidomide in the Treatment of Newly…(IFM 01/01) | Phase 3 | terminated | Mar 26, 2008 | Central Hospital, Nancy, France | survival advantage demonstrated | Other (stated, no rule matched) |
| NCT00510471 | Personalized Active Immunotherapy (Vaccine Therapy) and Sargramostim Given After Standard… | Phase 2 | terminated | Aug 2, 2007 | Genitope Corporation | not stated | Not stated |
| NCT00630903 | PUVA Versus PUVA + IFN Alpha 2a in Mycosis Fungoides(MF99) | Phase 4 | terminated | Mar 7, 2008 | Madrilenian Group of Cutaneous Lymphomas | Insufficient accrual | Enrollment / accrual |
| NCT00141700 | Study of Rituximab Plus High-Dose Chemotherapy Poor Prognosis Non-Hodgkin's Lymphoma | Phase 2 | terminated | Sep 1, 2005 | University of Michigan Rogel Cancer Center | enrollment completed | Enrollment / accrual |
| NCT00367497 | Safety and Efficacy Study of Salvage Chemotherapy (R-ESHAP) to Treat Relapsed and… | Phase 2 | terminated | Aug 23, 2006 | Keio University | The stopping rule was applied because of low response rates. | Other (stated, no rule matched) |
| NCT00120198 | Pegylated Liposomal Doxorubicin Containing Chemotherapy in the Treatment of Older… | Phase 2 | terminated | Jul 15, 2005 | Geriatric Oncology Consortium | slow accrual | Enrollment / accrual |
| NCT00057447 | Safety of Interferon Gamma-1b With Rituximab in Non-Hodgkin's Lymphoma Patients | Phase 1 / Phase 2 | terminated | Apr 3, 2003 | InterMune | administrative reasons | Other (stated, no rule matched) |
| NCT00100347 | Safety/Tolerance Study of PPI-2458 in Subjects With Non-Hodgkin's Lymphoma and Solid… | Phase 1 | terminated | Dec 30, 2004 | PRAECIS Pharmaceuticals Inc. | terminated due to corporate transaction. | Other (stated, no rule matched) |
| NCT00496743 | Study of Low-Dose Total Skin Electron Beam Therapy in Mycosis Fungoides | N/A | terminated | Jul 4, 2007 | Bispebjerg Hospital | The study was discontinued after the first 10 patients because of discouraging results. | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 22 days agoSource updated Apr 20, 2012source: clinicaltrials