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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
740 stopped studies mapped to Myeloproliferative Neoplasm and descendants · 88% state a reason
Over the 740 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT02029417 | Omacetaxine Mepesuccinate, Cytarabine, and Decitabine in Treating Older Patients With… | Phase 2 | terminated | Jan 7, 2014 | Roswell Park Cancer Institute | Major revisions needed in study | Other (stated, no rule matched) |
| NCT00579111 | Reduced Intensity Preparative Regimen Followed by Stem Cell Transplant (FAB) | Phase 1 / Phase 2 | terminated | Dec 21, 2007 | Baylor College of Medicine | slow accrual | Enrollment / accrual |
| NCT00578539 | T-Reg Cell Kinetics, Stem Cell Transplant, REGALE(REGALE) | N/A | terminated | Dec 21, 2007 | Baylor College of Medicine | not stated | Not stated |
| NCT02663648 | Cell Cycle Regulatory Gene Study in Patients With Myeloproliferative Disorders | — | withdrawn | Jan 26, 2016 | Shandong University | No eligible patient was enrolled. | Enrollment / accrual |
| NCT02221505 | Phase 1 Study of LOP628 in Adult Patients With cKit-positive Solid Tumors and Acute… | Phase 1 | terminated | Aug 20, 2014 | Novartis Pharmaceuticals | not stated | Not stated |
| NCT01573247 | Safety Study of AKN-028 in Patients With Acute Myelogenous Leukemia | Phase 1 / Phase 2 | terminated | Apr 9, 2012 | Akinion Pharmaceuticals AB | During the study two patients have experienced serious liver events related to AKN-028. The… | Other (stated, no rule matched) |
| NCT01455025 | Study in Plerixafor and Granulocyte-colony Stimulating Factor Patients With Relapse Acute…(PRIMAL) | Phase 1 | terminated | Oct 19, 2011 | French Innovative Leukemia Organisation | no recruitment on time | Enrollment / accrual |
| NCT00664677 | Phase 1 Study of Terameprocol (EM-1421) in Patients With Leukemia | Phase 1 | terminated | Apr 23, 2008 | Erimos Pharmaceuticals | Funding constraints | Funding |
| NCT00324077 | Phase I Study of Dasatinib (BMS-354825) and Imatinib in Subjects With Chronic Myeloid… | Phase 1 | withdrawn | May 10, 2006 | Bristol-Myers Squibb | Insufficient Enrollment | Enrollment / accrual |
| NCT00349518 | Study of Dasatinib in Imatinib Resistant or Intolerant Subjects With Chronic or Advanced… | Phase 2 / Phase 3 | withdrawn | Jul 7, 2006 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00660036 | Phase I/II Study of Mitoxantrone, Etoposide and Gemtuzumab Ozogamicin for Acute Myeloid… | Phase 1 | terminated | Apr 17, 2008 | University of Pittsburgh | due to new safety information | Safety / toxicity |
| NCT00630994 | Low-Dose Decitabine in Treating Patients With Symptomatic Myelofibrosis | Phase 2 | terminated | Mar 7, 2008 | Mayo Clinic | Stopped due to slow accrual | Enrollment / accrual |
| NCT01067274 | ALFA-0703 Study in Older Patients With Acute Myeloblastic Leukemia (AML)(ALFA-0703) | Phase 3 | withdrawn | Feb 11, 2010 | Acute Leukemia French Association | Study abandoned | Other (stated, no rule matched) |
| NCT00866281 | A Study of the Safety and Preliminary Efficacy of Oral Midostaurin (PKC412) in Relapsed… | Phase 1 / Phase 2 | terminated | Mar 20, 2009 | Novartis Pharmaceuticals | Despite considerable efforts to boost recruitment during the final year of the study, no new… | Enrollment / accrual |
| NCT01169753 | Nuvigil in Treatment of Cancer-Related Fatigue in Chronic Myeloid Leukemia Patients | N/A | terminated | Jul 26, 2010 | M.D. Anderson Cancer Center | Slow Enrollment | Enrollment / accrual |
| NCT02034227 | Safety, Tolerability Study of SG2000 in the Treatment of Advanced Chronic Lymphocytic… | Phase 1 / Phase 2 | terminated | Jan 13, 2014 | Spirogen | not stated | Not stated |
| NCT01211691 | Study of KB004 in Subjects With Hematologic Malignancies (Myelodysplastic Syndrome, MDS,… | Phase 1 / Phase 2 | suspended | Sep 29, 2010 | Humanigen, Inc. | KaloBios to Wind Down Operations | Other (stated, no rule matched) |
| NCT01670084 | Nilotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed… | Phase 2 | withdrawn | Aug 21, 2012 | Mayo Clinic | No Accrual | Enrollment / accrual |
| NCT00670150 | New Retinoid Agent Combined With Arsenic Trioxide for Untreated Acute Promyelocytic… | Phase 2 | withdrawn | May 1, 2008 | University of Southern California | sponsor withdrew support | Other (stated, no rule matched) |
| NCT00860535 | Growth Factor Signature (GFS) Pilot Study (MK0000-098)(COMPLETED) | Phase 1 | terminated | Mar 12, 2009 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT01794169 | Azacitidine Compared to Conventional Chemotherapy as Consolidation of Elderly Patients… | Phase 2 | terminated | Feb 18, 2013 | Karolinska University Hospital | Poor recruitment | Enrollment / accrual |
| NCT00464113 | Study of XL228 in Subjects With Chronic Myeloid Leukemia or… | Phase 1 | terminated | Apr 20, 2007 | Exelixis | Sponsor decision | Sponsor / business decision |
| NCT00595829 | A Phase 1 Study of XL019 in Adults With Polycythemia Vera | Phase 1 | terminated | Jan 16, 2008 | Exelixis | not stated | Not stated |
| NCT01260714 | Azacitidine, Mitoxantrone Hydrochloride, and Etoposide in Treating Older Patients With… | Phase 1 | terminated | Dec 15, 2010 | National Cancer Institute (NCI) | Inadequate accrual rate | Enrollment / accrual |
| NCT01489722 | Safety, Tolerability, Pharmacokinetics and Efficacy of AZD1208 in Acute Myelogenous… | Phase 1 | terminated | Dec 12, 2011 | AstraZeneca | not stated | Not stated |
| NCT01908387 | Phase 1 Study of CC-486 in Japanese Subjects With Hematological Neoplasms | Phase 1 | terminated | Jul 25, 2013 | Celgene Corporation | Due to Slow Accrual study was terminated. | Enrollment / accrual |
| NCT00374296 | MGCD0103 in Elderly Patients With Previously Untreated AML/High Risk MDS or Adults With… | Phase 2 | terminated | Sep 11, 2006 | Mirati Therapeutics Inc. | The Clinical Development Program for MGCD0103 is being re-evaluated | Other (stated, no rule matched) |
| NCT00963495 | Study Evaluating the Tolerance and Biological Activity of Oral Clioquinol in Patients… | Phase 1 | terminated | Aug 21, 2009 | University Health Network, Toronto | not stated | Not stated |
| NCT01222143 | Safety and Efficacy Study of Nilotinib Combined With Mitoxantrone, Etoposide, and… | Phase 1 / Phase 2 | terminated | Oct 18, 2010 | University Health Network, Toronto | not stated | Not stated |
| NCT01521936 | Cholecalciferol in Treating Patients With Acute Myeloid Leukemia Undergoing Intensive… | Phase 2 | terminated | Jan 31, 2012 | Roswell Park Cancer Institute | Lack of funding | Funding |
| NCT00800150 | Total Marrow and Total Lymph Node Irradiation, Fludarabine, and Melphalan Followed By… | Phase 1 | terminated | Dec 1, 2008 | City of Hope Medical Center | Protocol objective could not be met. A new study with amended eligibility criteria will be… | Other (stated, no rule matched) |
| NCT00952185 | Influenza Vaccine in Preventing Flu in Patients Who Have Undergone Stem Cell Transplant… | N/A | terminated | Aug 6, 2009 | City of Hope Medical Center | Very low enrollment and follow-up, cannot meet study objectives | Enrollment / accrual |
| NCT00770419 | Perceptions of Burden in Patients With Late-Stage Cancer and Their Caregivers | — | withdrawn | Oct 10, 2008 | Rutgers, The State University of New Jersey | Slow accrual | Enrollment / accrual |
| NCT00100152 | A Notch Signalling Pathway Inhibitor for Patients With T-cell Acute Lymphoblastic… | Phase 1 | terminated | Dec 24, 2004 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT01130688 | Safety of Zileuton (Zyflo) in Combination With Imatinib Mesylate (Gleevec) in CML. | Phase 1 | terminated | May 26, 2010 | University of Massachusetts, Worcester | Lack of enrollment | Enrollment / accrual |
| NCT01188889 | RAD001 in Patients With Chronic Phase Chronic Myeloid Leukemia w/ Molecular Disease. | Phase 1 / Phase 2 | withdrawn | Aug 26, 2010 | University of Michigan Rogel Cancer Center | Unable to obtain sufficient funding. | Funding |
| NCT00666497 | Phase 2 Study of Azacitidine (Vidaza) vs MGCD0103 vs Combination in Elderly Subjects With… | Phase 2 | terminated | Apr 25, 2008 | Mirati Therapeutics Inc. | Celgene terminated its collaboration agreement with MethylGene for the development of MGCD0103. All… | Other (stated, no rule matched) |
| NCT00669890 | Allogenic Stem Cell Transplantation in Patients With High Risk CD33+ AML/MDS/JMML(High Risk) | Phase 1 | terminated | May 1, 2008 | New York Medical College | PI left institution | Investigator |
| NCT00943553 | A Randomized Study of Epigenetic Priming Using Decitabine With Front Line Induction… | Phase 2 | withdrawn | Jul 22, 2009 | Eisai Inc. | Terminated by Sponsor | Other (stated, no rule matched) |
| NCT01065545 | The Role of Maintenance Oral Clofarabine in Older Adults With Acute Myeloid Leukemia | Phase 1 | withdrawn | Feb 9, 2010 | Northwestern University | Due to funding issues. | Funding |
| NCT01203228 | Dose-reduced Versus Standard Conditioning in MDS/sAML(RICMAC) | Phase 3 | terminated | Sep 16, 2010 | European Society for Blood and Marrow Transplantation | not stated | Not stated |
| NCT01010373 | Safety and Efficacy Study of AS101 to Treat Elderly Acute Myeloid Leukemia (AML) and… | Phase 2 | suspended | Nov 10, 2009 | BioMAS Ltd | The sponsor is currently focusing on different indications | Other (stated, no rule matched) |
| NCT00500006 | A Phase I Dose Escalation Combination Study in Patients With Chronic Myelogenous Leukemia… | Phase 1 | terminated | Jul 12, 2007 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT00114959 | Homoharringtonine With Oral Gleevec in Chronic, Accelerated and Blast Phase Chronic… | Phase 2 | terminated | Jun 21, 2005 | ChemGenex Pharmaceuticals | Poor enrollment | Enrollment / accrual |
| NCT01077440 | Presence of Donor-Derived DNA in Semen Samples From Cancer Survivors Who Underwent Donor… | — | terminated | Mar 1, 2010 | Vanderbilt University | PI leaving institution | Other (stated, no rule matched) |
| NCT01291784 | Anti-TGF-beta Therapy in Patients With Myelofibrosis | Phase 1 | terminated | Feb 8, 2011 | John Mascarenhas | Early termination when the drug was no longer made available by the pharmaceutical company due to… | Sponsor / business decision |
| NCT00907582 | ASCT for Relapsed APL After Molecular Remission | Phase 2 | terminated | May 22, 2009 | Shanghai Jiao Tong University School of Medicine | slow recruitment | Enrollment / accrual |
| NCT00940784 | Clopidogrel and Aspirin for the Treatment of Polycythemia Vera(ISCLAP) | Phase 2 | withdrawn | Jul 16, 2009 | Ronald Hoffman | Could not get drug | Other (stated, no rule matched) |
| NCT01650805 | Ponatinib in Newly Diagnosed Chronic Myeloid Leukemia (CML) (EPIC) | Phase 3 | terminated | Jul 26, 2012 | Ariad Pharmaceuticals | Study terminated based on evaluation of safety data. | Safety / toxicity |
| NCT02238522 | Phase 1 Study Evaluating ZEN003365 in Relapsed/Refractory Lymphoproliferative… | Phase 1 | withdrawn | Sep 12, 2014 | Zenith Epigenetics | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated May 9, 2016source: clinicaltrials