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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
648 stopped studies mapped to Myeloid Leukemia and descendants · 88% state a reason
Over the 648 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00720850 | Lenalidomide Maintenance Therapy in Patients With Myelodysplastic Syndromes (MDS) or…(LENAMAINT) | Phase 2 | terminated | Jul 23, 2008 | Technische Universität Dresden | Low recruitment, scientific rationale not applicable anymore to all patients and possible induction… | Enrollment / accrual |
| NCT01159301 | Entinostat and Sorafenib Tosylate in Treating Patients With Advanced or Metastatic Solid… | Phase 1 | terminated | Jul 9, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00514722 | Pilot Study of Umbilical Cord Blood Transplantation in Adult Patient With Advanced… | N/A | terminated | Aug 10, 2007 | University of California, San Francisco | low accrual | Enrollment / accrual |
| NCT00513318 | Pilot Study of Reduced-Intensity Umbilical Cord Blood Transplantation in Adult Patients… | — | terminated | Aug 8, 2007 | University of California, San Francisco | Insufficient enrollment to justify keeping open. | Enrollment / accrual |
| NCT00150878 | Standard vs. Reduced-Intensity Conditioning in Patients With Acute Myeloid Leukemia in… | Phase 3 | terminated | Sep 8, 2005 | University Hospital Carl Gustav Carus | Insurance coverage reached | Other (stated, no rule matched) |
| NCT00101231 | Flavopiridol in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia,… | Phase 1 | terminated | Jan 10, 2005 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00103272 | 17-N-Allylamino-17-Demethoxygeldanamycin and Bortezomib in Treating Patients With… | Phase 1 | terminated | Feb 8, 2005 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01463410 | Accuracy Testing of the Chromosomal Aberration and Gene Mutation Markers of the… | — | terminated | Nov 1, 2011 | Skyline Diagnostics BV | The required number of banked samples could not be met due to limited availability. There is no… | Other (stated, no rule matched) |
| NCT00658411 | Deferoxamine for Iron Overload Before Allogeneic Stem Cell Transplantation | N/A | terminated | Apr 15, 2008 | Dana-Farber Cancer Institute | Closed due to slow patient accrual | Enrollment / accrual |
| NCT00089388 | Cilengitide in Treating Patients With Acute Myeloid Leukemia | Phase 2 | terminated | Aug 5, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00096148 | Idarubicin and Cytarabine With or Without Bevacizumab in Treating Patients With Newly… | Phase 2 | terminated | Nov 9, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00023920 | Bevacizumab, Idarubicin, and Cytarabine in Treating Patients With Blast Phase Chronic… | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00042796 | Decitabine in Treating Children With Relapsed or Refractory Acute Myeloid Leukemia or… | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT01265199 | Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamic Properties of… | Phase 1 | terminated | Dec 23, 2010 | Ascenta Therapeutics | Study was terminated before a MTD was determined for administrative reasons | Other (stated, no rule matched) |
| NCT00101088 | Temsirolimus and Imatinib Mesylate in Treating Patients With Chronic Myelogenous Leukemia | Phase 1 | terminated | Jan 10, 2005 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00125606 | Phase 3 Trial for AML Patients in CR2 Comparing 8Gy TBI /Fludarabine to Conditioning With… | Phase 3 | terminated | Aug 1, 2005 | University Hospital Muenster | insufficient patient recruitement | Enrollment / accrual |
| NCT00790855 | Bendamustine in Acute Leukemia and MDS | Phase 1 / Phase 2 | terminated | Nov 14, 2008 | M.D. Anderson Cancer Center | Lack of Response | Other (stated, no rule matched) |
| NCT00038818 | CD8 DLI for Patients With Relapse or Residual Disease Following Allogeneic Stem Cell… | N/A | terminated | Jun 7, 2002 | M.D. Anderson Cancer Center | Low accrual. | Enrollment / accrual |
| NCT00480987 | Oxaliplatin, Fludarabine, and Cytarabine in Acute Myeloid Leukemia (AML) or High-Risk… | Phase 1 / Phase 2 | terminated | Jun 1, 2007 | M.D. Anderson Cancer Center | Lack of support. | Other (stated, no rule matched) |
| NCT00443300 | Effectiveness of Protected Environment Rooms for AML and MDS | — | terminated | Mar 5, 2007 | M.D. Anderson Cancer Center | Terminated due to low accrual. | Enrollment / accrual |
| NCT00513305 | Cytarabine in Combination With Arsenic Trioxide vs. Cytarabine Alone in Elderly Patients… | Phase 3 | terminated | Aug 8, 2007 | Cephalon | Study has been stopped by sponsor decision | Sponsor / business decision |
| NCT01558778 | Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem… | N/A | withdrawn | Mar 20, 2012 | Roswell Park Cancer Institute | device not available | Other (stated, no rule matched) |
| NCT00570999 | Palifermin After Haploidentical PBSCT(KGF Haplo Allo) | Phase 2 | withdrawn | Dec 11, 2007 | European Society for Blood and Marrow Transplantation | not stated | Not stated |
| NCT01066468 | Glivec/Gleevec Pediatric (Age 1 to Less Than 4) PK Study in CML, Ph+ ALL Patients and… | Phase 1 | terminated | Feb 10, 2010 | Novartis Pharmaceuticals | not stated | Not stated |
| NCT01452334 | Safety Study of Anti-Programmed Death-Ligand 1 in Hematologic Malignancy | Phase 1 | withdrawn | Oct 14, 2011 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00074750 | Study of DT388GMCSF Fusion Protein in Acute Myelogenous Leukemia (AML) and Chronic… | Phase 1 | terminated | Dec 23, 2003 | M.D. Anderson Cancer Center | Slow accrual. | Enrollment / accrual |
| NCT00895297 | Efficacy and Safety Study of Dasatinib in Patients With Chronic Myeloid Leukemia(Dasatinib) | Phase 2 | terminated | May 8, 2009 | European Society for Blood and Marrow Transplantation | Slow recruitment. No safety concerns during this study. | Safety / toxicity |
| NCT00519090 | Nilotinib vs Imatinib in Adult Patients With Philadelphia (Ph+) Chronic Myelogenous…(ENEST) | Phase 3 | terminated | Aug 21, 2007 | Novartis Pharmaceuticals | This study was terminated due to limited enrollment. | Enrollment / accrual |
| NCT01011998 | A Study of Imatinib and Valproic Acid in Patients With Chronic Myelogenous Leukemia (CML) | Phase 2 | withdrawn | Nov 11, 2009 | New Mexico Cancer Research Alliance | Withdrawn due to lack of accrual per Center DSMP, with PI concurrence | Enrollment / accrual |
| NCT00430443 | Liposomal Annamycin in Children and Young Adults With Refractory or Relapsed ALL or AML | Phase 1 | terminated | Feb 1, 2007 | Callisto Pharmaceuticals | Participants are no longer being examined or treated. | Other (stated, no rule matched) |
| NCT00839059 | Lenalidomide In Patients With Acute Myeloid Leukemia | Phase 1 | terminated | Feb 9, 2009 | University of Ulm | Results of an interim analysis and a hardly ongoing enrolment in the last 10 months in all six… | Efficacy / futility |
| NCT00162513 | Allogeneic Tumor Cell Vaccination in Patients With Chronic Myeloid Leukemia | Phase 1 / Phase 2 | withdrawn | Sep 13, 2005 | Hadassah Medical Organization | PI is no longer work at Hadassah | Other (stated, no rule matched) |
| NCT00531310 | Reduced Intensity AlloSCT in(CML) With Persistent Disease(CML) | Phase 2 | terminated | Sep 18, 2007 | Columbia University | Poor accrual | Enrollment / accrual |
| NCT00226512 | To Determine the Role of Adding Campath-1H or ATG Given In-vivo in Addition to… | Phase 3 | withdrawn | Sep 27, 2005 | Hadassah Medical Organization | the PI is no longer work at Hadassah | Other (stated, no rule matched) |
| NCT01034410 | A Study of AS1411 Combined With Cytarabine in the Treatment of Patients With Primary… | Phase 2 | terminated | Dec 17, 2009 | Antisoma Research | not stated | Not stated |
| NCT00486265 | Phase I/II, Open-label, Multi-center, Two Part Dose-escalation, Safety, Pharmacokinetics… | Phase 1 | terminated | Jun 14, 2007 | AstraZeneca | AML assess. of response in Part B patients find treatment failure in all 8 evaluable for marrow… | Other (stated, no rule matched) |
| NCT00279773 | Safety, Pharmacokinetics and Pharmacodynamics of TKI258 in Subjects With Acute Myeloid… | Phase 1 | terminated | Jan 20, 2006 | Novartis Pharmaceuticals | Study was stopped due to time dependent drug accumulation | Other (stated, no rule matched) |
| NCT00322673 | Study of XL999 in Patients With Acute Myeloid Leukemia (AML) | Phase 2 | terminated | May 8, 2006 | Symphony Evolution, Inc. | Study was terminated due to cardiac toxicities | Safety / toxicity |
| NCT00306332 | T-cell and B-cell Depletion in Allogeneic Peripheral Blood Stem Cell Transplantation | Phase 3 | terminated | Mar 23, 2006 | Radboud University Medical Center | Interim analysis has shown that the objectives of this study can not be reached | Efficacy / futility |
| NCT00543972 | Dose Escalation Safety and Pharmacokinetic Study of AVE9633 as Single Agent in… | Phase 1 | terminated | Oct 15, 2007 | Sanofi | due to absence of evidence of clinical activity up to toxic doses | Other (stated, no rule matched) |
| NCT00461929 | Chromosome Abnormalities in Chronic Myeloid Leukemia (CML) on Imatinib. GIST Patients on…(GIST) | Phase 4 | terminated | Apr 18, 2007 | University Health Network, Toronto | study terminated 12Feb09 due to low recruitment | Enrollment / accrual |
| NCT00594555 | A Study Evaluating the Effects of CLAG With Gleevec in Refractory or Relapsed Acute… | Phase 2 | withdrawn | Jan 15, 2008 | University of Cincinnati | Principal Investigator resigned position with the University of Cincinnati, closing study at this… | Investigator |
| NCT00363025 | A Randomized Study of Post-Remission Therapy in Elderly Patients With Acute Myelogenous… | Phase 3 | terminated | Aug 15, 2006 | Acute Leukemia French Association | not stated | Not stated |
| NCT00104468 | Study of Troxatyl™ Administered by Continuous Infusion to Subjects With Refractory Acute… | Phase 1 / Phase 2 | terminated | Mar 1, 2005 | SGX Pharmaceuticals, Inc. | Trial stopped June 2007 | Other (stated, no rule matched) |
| NCT00511121 | Study of the Combination of a Tyrosine Kinase Inhibitor (STI571) and a Pegylated Human… | Phase 2 | terminated | Aug 3, 2007 | University of Bologna | not stated | Not stated |
| NCT00126893 | Study to Determine the Optimal Biologic Dose of CC-401 in Subjects With High-Risk Myeloid… | Phase 1 | terminated | Aug 5, 2005 | Celgene Corporation | not stated | Not stated |
| NCT00329498 | L-Ascorbic Acid Depletion to Treat Acute Myeloid Leukemia and Myelodysplastic Syndromes | Phase 2 | suspended | May 24, 2006 | Samsung Medical Center | not stated | Not stated |
| NCT00219765 | Safety and Efficacy of Imatinib in Combination With High Dose Chemotherapy for Acute… | Phase 1 / Phase 2 | terminated | Sep 22, 2005 | Poitiers University Hospital | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 22 days agoSource updated Sep 27, 2013source: clinicaltrials