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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
328 stopped studies mapped to Myelodysplastic Syndrome and descendants · 88% state a reason
Over the 328 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01101412 | Antimicrobial Solution or Saline Solution in Maintaining Catheter Patency and Preventing… | Phase 1 / Phase 2 | withdrawn | Apr 12, 2010 | M.D. Anderson Cancer Center | Study was not opened. | Other (stated, no rule matched) |
| NCT00006220 | Arsenic Trioxide With or Without Tretinoin in Treating Patients With Hematologic Cancer… | Phase 1 / Phase 2 | terminated | May 20, 2004 | Washington University School of Medicine | Study drug became commercially available. | Other (stated, no rule matched) |
| NCT00005641 | Removal of T Cells to Prevent Graft-Versus-Host Disease in Patients Undergoing Bone… | Phase 2 | terminated | Jun 8, 2004 | H. Lee Moffitt Cancer Center and Research Institute | low study accrual | Enrollment / accrual |
| NCT00005852 | Bone Marrow Transplantation in Treating Patients With Severe Aplastic Anemia or Rejection… | Phase 2 | terminated | Jul 26, 2004 | H. Lee Moffitt Cancer Center and Research Institute | low accrual | Enrollment / accrual |
| NCT00790855 | Bendamustine in Acute Leukemia and MDS | Phase 1 / Phase 2 | terminated | Nov 14, 2008 | M.D. Anderson Cancer Center | Lack of Response | Other (stated, no rule matched) |
| NCT00069992 | Total-Body Irradiation, Fludarabine, and Alemtuzumab Followed By Stem Cell Transplant in…(MPDMDSBMT) | Phase 2 | terminated | Oct 7, 2003 | Baylor College of Medicine | Closed due to competing protocols | Other (stated, no rule matched) |
| NCT00301912 | Busulfan and Fludarabine Before Donor Stem Cell Transplant in Treating Patients With… | Phase 2 | withdrawn | Mar 13, 2006 | University of California, San Francisco | Withdrawn because study never opened to accrual | Enrollment / accrual |
| NCT00062231 | Moxifloxacin Compared With Ciprofloxacin/Amoxicillin in Treating Fever and Neutropenia in… | N/A | terminated | Jun 6, 2003 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT00676728 | A Study of the Histone-deacetylase Inhibitor JNJ-26481585 in Patients With Advanced or… | Phase 1 | terminated | May 13, 2008 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Sponsor Decision | Sponsor / business decision |
| NCT00113321 | Low-Dose Decitabine in Myelodysplastic Syndrome Post Azacytidine Failure | Phase 2 | terminated | Jun 8, 2005 | M.D. Anderson Cancer Center | Low Accrual | Enrollment / accrual |
| NCT00480987 | Oxaliplatin, Fludarabine, and Cytarabine in Acute Myeloid Leukemia (AML) or High-Risk… | Phase 1 / Phase 2 | terminated | Jun 1, 2007 | M.D. Anderson Cancer Center | Lack of support. | Other (stated, no rule matched) |
| NCT00443300 | Effectiveness of Protected Environment Rooms for AML and MDS | — | terminated | Mar 5, 2007 | M.D. Anderson Cancer Center | Terminated due to low accrual. | Enrollment / accrual |
| NCT00960726 | NOV-002 in Myelodysplastic Syndrome (MDS) | Phase 2 | withdrawn | Aug 18, 2009 | M.D. Anderson Cancer Center | Study withdrawn at sponsor request. | Other (stated, no rule matched) |
| NCT00893997 | PR1 Vaccination in Myelodysplastic Syndrome (MDS) | Phase 2 | terminated | May 6, 2009 | M.D. Anderson Cancer Center | The trial was ended per sponsor due to slow accrual rates. | Enrollment / accrual |
| NCT01558778 | Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem… | N/A | withdrawn | Mar 20, 2012 | Roswell Park Cancer Institute | device not available | Other (stated, no rule matched) |
| NCT00886496 | Recombinant Human Mannose-Binding Lectin (MBL) in Treating Young Patients With MBL… | Phase 1 | withdrawn | Apr 23, 2009 | Enzon Pharmaceuticals, Inc. | No participants enrolled. IND withdrawn. | Enrollment / accrual |
| NCT00253552 | G-CSF-Treated Donor Bone Marrow Transplant in Treating Patients With Hematologic Disorders | N/A | terminated | Nov 15, 2005 | OHSU Knight Cancer Institute | Terminated at request of PI as study was outdated. | Other (stated, no rule matched) |
| NCT00570999 | Palifermin After Haploidentical PBSCT(KGF Haplo Allo) | Phase 2 | withdrawn | Dec 11, 2007 | European Society for Blood and Marrow Transplantation | not stated | Not stated |
| NCT00827099 | Umbilical Cord Blood (UCB) Transplant, Fludarabine, Melphalan, and Anti-thymocyte… | Phase 2 | terminated | Jan 22, 2009 | Northside Hospital, Inc. | Unacceptable morbidity \& mortality | Other (stated, no rule matched) |
| NCT01546337 | Search for Predictive Markers of Efficacy of ESAs in Patients With Non-myeloid…(EPO) | — | terminated | Mar 7, 2012 | Rennes University Hospital | not stated | Not stated |
| NCT00446303 | A Phase II Study of Maintenance With Azacitidine in MDS Patients | Phase 2 | terminated | Mar 12, 2007 | Groupe Francophone des Myelodysplasies | not stated | Not stated |
| NCT00915811 | Pilot Study of Reduced Intensity Haematopoietic Stem Cell Transplantation in Patients…(FB-ATG) | Phase 2 | terminated | Jun 8, 2009 | King's College Hospital NHS Trust | FB ATG is now a standard for sib allo MDS patients | Other (stated, no rule matched) |
| NCT00226512 | To Determine the Role of Adding Campath-1H or ATG Given In-vivo in Addition to… | Phase 3 | withdrawn | Sep 27, 2005 | Hadassah Medical Organization | the PI is no longer work at Hadassah | Other (stated, no rule matched) |
| NCT00813501 | Immunologic Diagnostic Blood Test in Predicting Side-Effects in Patients Undergoing a… | — | terminated | Dec 23, 2008 | City of Hope Medical Center | Terminated at the request of the study sponsor | Other (stated, no rule matched) |
| NCT00004058 | 12-O-Tetradecanoylphorbol-13-acetate in Treating Patients With Hematologic Cancer or Bone… | Phase 1 | terminated | Jan 27, 2003 | University of Medicine and Dentistry of New Jersey | At this time it is felt that we will not gain further information from an additional patients. | Other (stated, no rule matched) |
| NCT00306332 | T-cell and B-cell Depletion in Allogeneic Peripheral Blood Stem Cell Transplantation | Phase 3 | terminated | Mar 23, 2006 | Radboud University Medical Center | Interim analysis has shown that the objectives of this study can not be reached | Efficacy / futility |
| NCT00143884 | Study of Low Intensity Conditioning and Immunotherapy for High-Risk Cancers of the Blood | Phase 2 | terminated | Sep 2, 2005 | University of Michigan Rogel Cancer Center | not stated | Not stated |
| NCT00329498 | L-Ascorbic Acid Depletion to Treat Acute Myeloid Leukemia and Myelodysplastic Syndromes | Phase 2 | suspended | May 24, 2006 | Samsung Medical Center | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 22 days agoSource updated Feb 15, 2013source: clinicaltrials